核磁共振技术在药物检测中的应用进展  

Application progress of nuclear magnetic resonance in pharmaceutical detection

作　　者：刘雅琴[1] 余明新[1] 何玲[1] LIU Ya-qin;YU Ming-xin;HE Ling(Department of Chemistry,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江大学化学系,杭州310027

出　　处：《天然产物研究与开发》2022年第11期1971-1977,共7页Natural Product Research and Development

基　　金：浙江省科技厅公益技术研究计划(LGC19B050014)。

摘　　要：核磁共振(nuclear magnetic resonance, NMR)技术已发展成为新化合物结构鉴定和天然产物药物分析不可缺少的工具。因其具有非破坏性和无侵入性等特点,广泛应用于药物领域,从合成产物的表征到生物系统分子结构和构象的测定以及分析分子间相互作用等研究都离不开这个工具。核磁共振能提供丰富且精确的结构信息,如拉莫尔频率、化学位移、自旋-自旋偶合、偶极偶合和弛豫时间等参数,成为结构解析的“金标准”。本文总结了核磁共振技术在药物发现、药物相互作用、药物代谢组学以及固态核磁共振技术在固态药物分析中的应用进展。Nuclear magnetic resonance(NMR) technology has evolved into an indispensable tool for the structural identification of new compounds and the analysis of natural products.Because of its non-destructive and non-invasive characteristics, it is widely used in the field of pharmaceuticals, from the characterization of synthetic products to the determination of molecular structure and conformation of biological systems and the analysis of molecular interactions.NMR can provide rich and accurate structural information, such as Larmor frequency, chemical shift, spin-spin coupling, dipole coupling, relaxation time and other parameters, which is becoming the "gold standard" for structural analysis.The paper summarizes the application and research progress of NMR in drug discovery, drug interaction, drug metabolomics and solid-state NMR(ss NMR) in solid-state drug analysis.

关 键 词：核磁共振技术 药物发现 药物检测 药物相互作用 药物代谢组学 固态核磁共振 

分 类 号：O657[理学—分析化学] R917[理学—化学]