依达拉奉右莰醇联合丁苯酞治疗脑血管病的临床观察  

Clinical effect of edalavondendol combined with butylphthalide in the treatment of cerebrovascular disease

作　　者：刘小双[1] 张凯[1] 苏楠[1] Liu Xiaoshuang;Zhang Kai;Su Nan(Puyang People’s Hospital,Puyang 457000,China)

机构地区：[1]濮阳市人民医院,濮阳457000

出　　处：《中国实用医刊》2022年第16期97-100,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析依达拉奉右莰醇联合丁苯酞治疗脑血管病的效果及其对患者神经功能及预后的影响。方法抽取2021年6月至2022年4月濮阳市人民医院收治的脑血管病患者60例,根据治疗方案将其分为研究组和对照组,每组30例。对照组采用依达拉奉右莰醇治疗,研究组采用依达拉奉右莰醇联合丁苯酞治疗。治疗14 d,比较两组患者神经功能、预后改善情况,评价治疗效果。结果①研究组总有效率(96.67%,29/30)高于对照组(76.67%,23/30),差异有统计学意义(χ^(2)=5.19,P<0.05)。②治疗14 d,研究组美国国立卫生研究院卒中量表评分[(9.1±1.2)分]低于对照组[(14.2±1.4)分],差异有统计学意义(t=15.15,P<0.05)。③治疗8周,研究组脑血流动力指标中最小血流量为(5.4±0.7)cm/s,最小血流速度为(10.7±0.9)cm/s,高于对照组的(4.7±0.4)、(9.5±1.1)cm/s,差异有统计学意义(t=4.76、4.62,P均<0.05)。④研究组死亡率(0,0/30)、重度残疾率(3.33%,1/30)、植物生存率(3.33%,1/30)低于对照组[3.33%(1/30)、10.00%(3/30)、13.33%(4/30)];研究组不良反应发生率(6.67%,2/30)低于对照组(26.67%,8/30),差异有统计学意义(χ^(2)=4.32,P<0.05)。结论依达拉奉右莰醇联合丁苯酞治疗脑血管病,可疏通血管,改善脑动力学指标,保护神经功能,改善患者预后。Objective To analyze the effect of edalavondendol combined with butylphthalide in the treatment of cerebrovascular disease,and its influence on the neurological function and prognosis of patients.Methods A total of 60 patients with cerebrovascular disease admitted to Puyang People’s Hospital from June 2021 to April 2022 were selected,and the patients were divided into a study group and a control group according to the treatment plans,with 30 cases in each group.The control group was treated with edalavondendol,and the study group was treated with edalavondendol combined with butylphthalide.Patients were treated for 14 days.The neurological function and prognosis improvement of the two groups were compared,and the treatment effect was evaluated.Results The total effective rate of the study group(96.67%,29/30)was higher than that of the control group(76.67%,23/30),χ^(2)=5.19,P<0.05.After 14 days of treatment,the National Institutes of Health Stroke Scale score of the study group(9.1±1.2)was lower than that of the control group(14.2±1.4),and the difference was significant(t=15.15,P<0.05).After 8 weeks of treatment,the minimum blood flow in the cerebral hemodynamic indexes of the study group was(5.4±0.7)cm/s,and the minimum blood flow velocity was(10.7±0.9)cm/s,which were higher than(4.7±0.4)cm/s and(9.5±1.1)cm/s of the control group,correspondingly,and the difference was statistically significant(t=4.76,4.62;all P<0.05).The mortality rate(0,0/30),severe disability rate(3.33%,1/30),and plant survival rate(3.33%,1/30)in the study group were lower than those in the control group(3.33%,1/30;10.00%,3/30;13.33%,4/30);the incidence of adverse reactions in the study group(6.67%,2/30)was lower than that in the control group(26.67%,8/30),and the difference was statistically significant(χ^(2)=4.32,P<0.05).Conclusions Edalavondendol combined with butylphthalide in the treatment of cerebrovascular disease can clear blood vessels,improve cerebral dynamic indexes,protect neurological function,and improve the prognosis of

关 键 词：丁苯酞 脑血管病 依达拉奉右莰醇 神经功能 

分 类 号：R743[医药卫生—神经病学与精神病学]