叶酸受体阳性循环肿瘤细胞检测对早期肺癌的诊断价值  

Diagnostic value of folate receptor-positive circulating tumor cells in early lung cancer

作　　者：陈鹏飞 谢金标[1] 杨天宝[1] 王武[1] 陈豪[1] 黄国忠[1] CHEN Pengfei;XIE Jinbiao;YANG Tianbao;WANG Wu;CHEN Hao;HUANG Guozhong(Department of Cardiothoracic Surgery,the Affiliated Hospital of Putian University,Fujian Province,Putian 351100,China)

机构地区：[1]莆田学院附属医院心胸外科,福建莆田351100

出　　处：《中国当代医药》2022年第32期79-81,共3页China Modern Medicine

基　　金：莆田学院校内科研项目(2019090)。

摘　　要：目的研究分析叶酸受体阳性循环肿瘤细胞检测对早期肺癌的临床诊断价值。方法选取2019年9月至2021年12月莆田学院附属医院心胸外科收治的100例胸部CT影像学疑似肺癌患者作为研究对象,收集100例患者的血液样本,在前肘静脉操作并储存于4℃的温度下,并将血液标本于24 h之内完成叶酸受体阳性循环肿瘤细胞检测。结果结合患者的病理诊断结果,有75例早期肺癌患者,25例肺良性病变患者,早期肺癌患者的叶酸受体阳性肿瘤细胞数量高于肺良性病变患者,差异有统计学意义(P<0.05)。以术后病理结果作为诊断肺癌的金标准,Kappa一致性检验显示叶酸受体阳性循环肿瘤诊断早期肺癌具有一定的准确性(Kappa=0.683,P<0.05);以叶酸受体阳性循环肿瘤细胞作为肺癌的诊断指标,ROC曲线下面积为0.810(95%CI=0.648~1.000),最佳截断值为8.7 FU/3 ml,灵敏度为87.7%,特异度为76.9%。结论临床上,叶酸受体阳性循环肿瘤细胞检测对早期肺癌的诊断具有较好的诊断效能。Objective To study and analyze the clinical diagnostic value of folate receptor-positive circulating tumor cells for early lung cancer.Methods A total of 100 patients with suspected lung cancer on chest CT imaging treated in the Department of Cardiothoracic Surgery of the Affiliated Hospital of Putian University from September 2019 to December 2021 were selected as the research objects.The blood samples of 100 patients were collected,operated in the anterior elbow vein and stored at a temperature of 4℃,and the blood samples were tested for folate receptor positive circulating tumor cells within 24 h.Results Combined with the pathological diagnosis results of the patients,there were 75 patients with early stage lung cancer and 25 patients with benign lung lesions,the quantity of folate receptor-positive tumor cells in patients with early lung cancer was higher than that in patients with benign lung disease,the difference was statistically significant(P<0.05).Taking postoperative pathological results as the gold standard for diagnosing lung cancer,Kappa consistency test showed that folate receptor positive circulating tumor had a certain accuracy in the diagnosis of early lung cancer(Kappa=0.683,P<0.05).Folate receptor positive circulating tumor cells were used as diagnostic indicators for lung cancer,the area under the ROC curve was 0.837(95%CI=0.648-1.000),the optimal cut-off value was 8.7 FU/3 ml,the sensitivity was 87.7%,and the specificity was 76.9%.Conclusion The detection of folate receptor-positive circulating tumor cells has good diagnostic performance in the diagnosis of early lung cancer.

关 键 词：叶酸受体阳性循环肿瘤细胞 早期肺癌 临床诊断价值 灵敏度 特异度 

分 类 号：R734.2[医药卫生—肿瘤]