艾司西酞普兰联合高频重复经颅磁刺激治疗首发抑郁症对事件相关电位P300、MMN的影响  

Effects of Escitalopram combined with high-frequency repetitive transcranial magnetic stimulation on event-related potential P300 and MMN in the treatment of first-episode depression

作　　者：刘洁 何婉婷 郑玉玲 叶秀儿 梁光辉 唐瑞强 LIU Jie;HE Wanting;ZHENG Yuling;YE Xiuer;LIANG Guanghui;TANG Ruiqiang(Outpatient Department,Dongguan Seventh People's Hospital,Guangdong Province,Dongguan 523220,China;Department of Psychiatry,Dongguan Seventh People's Hospital,Guangdong Province,Dongguan 523220,China;Treatment Area,Dongguan Seventh People's Hospital,Guangdong Province,Dongguan 523220,China;Department of Physical Therapy,Dongguan Seventh People's Hospital,Guangdong Province,Dongguan 523220,China;Department of Adolescent Psychology,Dongguan Seventh People's Hospital,Guangdong Province,Dongguan 523220,China)

机构地区：[1]广东省东莞市第七人民医院门诊部,广东东莞523220 [2]广东省东莞市第七人民医院精神科,广东东莞523220 [3]广东省东莞市第七人民医院救治区,广东东莞523220 [4]广东省东莞市第七人民医院物理治疗科,广东东莞523220 [5]广东省东莞市第七人民医院青少年心理科,广东东莞523220

出　　处：《中国当代医药》2022年第31期24-27,共4页China Modern Medicine

基　　金：广东省东莞市社会发展科技项目(20211800902512)。

摘　　要：目的探讨艾司西酞普兰联合高频重复经颅磁刺激(rTMS)治疗首发抑郁症对事件相关电位P300、失匹配负波(MMN)的影响。方法选择2021年10月至2022年3月东莞市第七人民医院收治的100例首发抑郁症患者作为研究对象,按随机数字表法分成单药治疗组、联合治疗组,每组各50例。单药治疗组采用艾司西酞普兰联合伪刺激治疗,联合治疗组采用艾司西酞普兰联合高频rTMS治疗。持续治疗8周后,对比两组患者抑郁状态[汉密尔顿抑郁量表-17(HAMD-17)]、认知功能[蒙特利尔认知评估量表(MoCA)]及事件相关电位P300、MMN。结果两组患者治疗第8周末的HAMD-17评分均低于治疗前,且联合治疗组低于单药治疗组,差异有统计学意义(P<0.05);两组患者治疗第8周末的MoCA评分均高于治疗前,且联合治疗组高于单药治疗组,差异有统计学意义(P<0.05);两组患者治疗第8周末事件相关电位N1、P2、N2、P3及MMN潜伏期均短于治疗前,波幅高于治疗前,差异有统计学意义(P<0.05);联合治疗组治疗第8周末的事件相关电位N1、P2、N2、P3及MMN潜伏期均短于单药治疗组,波幅高于单药治疗组,差异有统计学意义(P<0.05)。结论艾司西酞普兰联合高频rTMS治疗能进一步减轻首发抑郁症患者的抑郁状态,改善对事件相关电位P300、MMN,促进认知功能恢复,值得提倡。Objective To explorer the effects of Escitalopram combined with high-frequency repetitive transcranial magnetic stimulation(rTMS)on event-related potential P300 and mismatch negativity(MMN)in the treatment of first-episode depression.Methods A total of 100 patients with first-episode depression treated in Dongguan Seventh People's Hospital from October 2021 to March 2022 were selected as research objects,and they were divided into single drug treatment group and combined treatment group according to random number table method,with 50 cases in each group.The single drug treatment group was treated with Escitalopram combined with pseudo stimulation,and the combined treatment group was treated with Escitalopram combined with high-frequency rTMS.After 8 weeks of continuous treatment,the depression status(Hamilton depression scale-17[HAMD-17]),cognitive function(Montreal cognitive assessment[MoCA]),event-related potential P300 and mismatch negativity(MMN)were compared between the two groups.Results The HAMD-17 score of the two groups at the end of the 8^(th) week of treatment were lower than those before treatment,and the combined treatment group was lower than that of the single drug treatment group,with statistically significant differences(P<0.05).The MOCA score of the two groups at the end of the 8^(th) week of treatment were higher than those before treatment,and the combined treatment group was higher than that of the single drug treatment group,with statistically significant differences(P<0.05).At the end of the 8^(th) week after treatment,the latency of event-related potentials N1,P2,N2,P3 and MMN in the two groups were shorter than those before treatment,and the amplitude was higher than that before treatment,with statistically significant differences(P<0.05).The latency of event-related potentials N1,P2,N2,P3 and MMN in the combined treatment group at the 8^(th) weekend were shorter than those in the single drug treatment group,and the amplitude was higher than that in the single drug treatment group,with st

关 键 词：艾司西酞普兰 高频重复经颅磁刺激 首发抑郁症 事件相关电位 

分 类 号：R749[医药卫生—神经病学与精神病学]