乳腺癌超声毛刺征患者的相关免疫组合指标表达情况  

Expression of related immune combination indicators in breast cancer patients with ultrasound burr sign

作　　者：周亮[1] 马亚楠 ZHOU Liang;MA Ya′nan(Department of Ultrasound,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Uygur Autonomous Region,Urumqi830001,China)

机构地区：[1]新疆维吾尔自治区人民医院超声科,新疆乌鲁木齐830001

出　　处：《中国当代医药》2022年第31期129-132,共4页China Modern Medicine

基　　金：新疆维吾尔自治区人民医院院内项目(20190415)。

摘　　要：目的探讨乳腺癌超声毛刺征患者雌激素受体(ER)、孕激素受体(PR)、人类表皮因子受体-2(HER-2)和Ki-67的表达情况。方法回顾性选取2019年1月至2020年12月新疆维吾尔自治区人民医院收治的207例乳腺癌患者作为研究对象,根据超声毛刺征的特点分为无毛刺组(55例)和有毛刺组(152例),其中有毛刺组又细分为基底部<1 mm的微毛刺、1~2 mm的毛刺和>2 mm的毛刺三组。比较两组患者ER、PR、HER-2和Ki-67的阳性表达率。结果有毛刺组的ER、PR阳性表达率分别为82.2%、78.9%,高于无毛刺组的34.5%、30.9%,差异有统计学意义(P<0.05);两组患者的Her-2和Ki-67阳性表达率比较,差异无统计学意义(P>0.05)。不同基底宽度的毛刺征患者比较结果显示,1~2 mm基底宽度毛刺征患者的ER、PR阳性表达率最高,差异有统计学意义(P<0.05)。结论ER和PR阳性表达率与乳腺癌超声毛刺征关系密切,可为鉴别乳腺良恶性肿块及术前乳腺癌患者治疗方式的选择提供一定的参考依据。Objective To investigate the expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal factor receptor-2(HER-2)and Ki-67 in breast cancer patients with ultrasound burr sign.Methods A total of 207 breast cancer patients admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from January 2019 to December 2020 were retrospectively selected as the research objects.According to the characteristics of ultrasonic burr sign,the patients were divided into non-burr group(55 cases)and burr group(152 cases).The burr group was further subdivided into three groups:micro burr<1 mm at the base,1-2 mm burr and>2 mm burr.The positive expression rates of ER,PR,HER-2 and Ki-67 were compared between the two groups.Results The positive expression rates of ER and PR in the burr group were 82.2%and 78.9%,respectively,which were higher than those in the non-burr group(34.5%and 30.9%,P<0.05).There was no significant difference in the positive expression rates of HER-2 and Ki-67 between the two groups(P>0.05).The comparison results of patients with burr sign with different base widths showed that the positive expression rates of ER and PR in patients with burr sign with 1-2 mm base width were the highest,and the difference was statistically significant(P<0.05).Conclusion The positive expression rates of ER and PR are closely related to the ultrasonic burr sign of breast cancer,which can provide a certain reference for the differentiation of benign and malignant breast tumors and the selection of preoperative treatment for breast cancer patients.

关 键 词：乳腺癌 毛刺征 免疫组化 阳性表达率 

分 类 号：R737.9[医药卫生—肿瘤]