神经干细胞移植在缺血性卒中治疗中的作用  

Roles of neural stem cells transplantation in the treatment of ischemic stroke

作　　者：李孔平 彭林辉 左夏林[1] 徐恩[1] Li Kongping;Peng Linhui;Zuo Xialin;Xu En(Institute of Neurosciences,Guangzhou Medical University,Department of Neurology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China)

机构地区：[1]广州医科大学神经科学研究所,广州医科大学附属第二医院神经内科,510260

出　　处：《中国脑血管病杂志》2022年第11期778-782,F0003,共6页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金项目(81971233)。

摘　　要：神经干细胞(NSCs)是一类具有自我更新能力,能够分化为神经细胞、胶质细胞和少突胶质细胞的多潜能细胞。NSCs移植到体内后,通过神经细胞替代方式,重新连接受损的神经环路;通过旁分泌效应,释放免疫调节因子和营养因子,促进神经损伤的修复。作者对NSCs移植在缺血性卒中治疗中的作用及机制进行了综述,以期为缺血性卒中后组织重构与功能恢复的相关研究提供理论参考。Neural stem cells(NSCs) are self-renewing pluripotent cells characterized by the ability to differentiate along the neural lineage into any of three types: neurons, glia and oligodendrocytes. After NSCs are transplanted into the host, on the one hand the damaged neural circuits are reconnected through neuron replacement, on the other hand, immune regulators and trophic factors are released to promote the repair of neural damage through paracrine effects. In this paper, the authors reviewed the role and mechanism of NSCs transplantation in the treatment of ischemic stroke, to provide theoretical evidences for brain tissue remodeling and functional recovery after cerebral ischemia.

关 键 词：神经干细胞 缺血性卒中 神经再生 神经保护 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]