明目地黄汤联合曲安奈德治疗老年性白内障临床研究  

Clinical Study on Mingmu Dihuang Tang Combined with Triamcinolone Acetonide for Senile Cataract

作　　者：迟新建 王静 李晓楠 杨新霞 马建黎 CHI Xinjian;WANG Jing;LI Xiaonan;YANG Xinxia;MA Jianli

机构地区：[1]确山县人民医院五官科,河南确山463200

出　　处：《新中医》2022年第18期109-112,共4页New Chinese Medicine

摘　　要：目的:观察明目地黄汤联合曲安奈德治疗老年性白内障的临床疗效。方法:选择老年性白内障患者72例,随机分为对照组和研究组各36例。对照组在常规对症治疗的基础上给予曲安奈德治疗,研究组在对照组的基础上给予明目地黄汤治疗。2组疗程均为3个月,观察比较2组总有效率,以及2组治疗前后视力变化、炎症因子[白细胞介素6 (IL-6)、肿瘤坏死因子-α (TNF-α)、超敏C-反应蛋白(hs-CRP)]水平及氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、脂质过氧化物(LPO)]变化。结果:治疗后,研究组总有效率为94.44%,对照组为83.33%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组视力水平比较,差异无统计学意义(P>0.05);治疗1、2、3个月,2组视力水平均较治疗前升高(P<0.05),且研究组在相同治疗时间点的视力水平明显高于对照组(P<0.05)。治疗前,2组血清IL-6、TNF-α、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后,2组血清IL-6、TNF-α、hs-CRP水平均较治疗前降低(P<0.05),且研究组上述各项指标均低于对照组(P<0.05)。治疗前,2组氧化应激指标MDA、SOD、LPO水平比较,差异无统计学意义(P>0.05);治疗后,2组SOD水平较治疗前升高(P<0.05),MDA、LPO水平较治疗前降低(P<0.05),且研究组上述各项指标改善较对照组更显著(P<0.05)。结论:明目地黄汤联合曲安奈德治疗老年性白内障疗效显著,可有效改善患者的视力,降低炎症因子水平,提高机体抗氧化能力。Objective: To observe the clinical effect of Mingmu Dihuang tang combined with triamcinolone acetonide for senile cataract. Methods:A total of 72 cases of patients with senile cataract were selected and randomly divided into the control group and the study group, with 36 cases in each group. The control group was treated with triamcinolone acetonide based on routine symptomatic treatment,and the study group was additionally treated with Mingmu Dihuang tang based on the treatment of the control group. Both groups were treated for three months. The changes in visual acuity,the levels of inflammatory factors including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α) and high-sensitivity C-reactive protein(hs-CRP), and oxidative stress indexes including malondialdehyde(MDA), superoxide dismutase(SOD) and lipid peroxidation(LPO) before and after treatment as well as the total effective rates in the two groups were observed and compared. Results: After treatment, the total effective rate was94.44% in the study group and 83.33% in the control group, the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of visual acuity between the two groups(P>0.05). After one, two and three months of treatment, the levels of visual acuity in the two groups were increased when compared with those before treatment(P<0.05),and the level of visual acuity in the study group was significantly higher than that in the control group at the same treatment time point(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of IL-6,TNF-α and hs-CRP in serum between the two groups(P>0.05). After treatment, the levels of IL-6, TNF-α and hs-CRP in serum in the two groups were decreased when compared with those before treatment(P<0.05), and the above indexes in the study group were lower than those in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of t

关 键 词：老年性白内障 明目地黄汤 曲安奈德 视力 氧化应激指标 

分 类 号：R776.1[医药卫生—眼科]