Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia  

作　　者：Zhilan Yang Hongying Pan Lan Jiang Yuhang Liang Jie Wu 

机构地区：[1]Department of Clinical Psychology,The Affiliated Mental Hospital of Kunming Medical University,Kunming 650000,China

出　　处：《Journal of Translational Neuroscience》2022年第1期1-5,共5页转化神经科学电子杂志（英文）

基　　金：Yunnan Provincial Department of Science and Technology Project(202101AY070001-224).

摘　　要：Schizophrenia(SCZ)is the most common serious mental illness with a high disability rate and heavy social and family burdens.At present,there is no clear etiology and pathogenesis of schizophrenia.Studies have shown that the occurrence of schizophrenia may be related to the abnormality of the hypothalamic-pituitary-adrenal(HPA)axis.The LIM-homeobox gene 3(LHXS)and early growth response 1(EGR1)can affect pituitary function.Because the synapsin 2(SYN2)gene polymorphism regulates the activity of LHX3 and EGR1,it may cause the occurrence of schizophrenia.This article will review the possible involvement of SYN2 gene polymorphism in the pathogenesis of schizophrenia via regulating the activity of LHX3 and EGR1,then to afiect the HPA axis.

关 键 词：schizophrenia(SCZ) hypothalamic-pituitary-adrenal(HPA)axis synapsin 2(SYN2) LIM-homeobox gene 3(Z/ZY3) early growth response 1(EGR1) 

分 类 号：R749.3[医药卫生—神经病学与精神病学]