PLAU和AKT1在口腔鳞癌中的表达  

Expression of PLAU and AKT1 in oral squamous cell carcinoma

作　　者：孙二灿 肖巧玲[1] 夏飞飞 刘喆 徐江[2] 黎昌学[1] Sun Ercan;Xiao Qiaoling;Xia Feifei;Liu Zhe;Xu Jiang;Li Changxue(School of Medicine,Shihezi University,Shihezi 832000;Dept of Stomatology,The First Affiliated Hospital of Shihezi University Medical College,Shihezi 832000)

机构地区：[1]石河子大学医学院,石河子832000 [2]石河子大学医学院第一附属医院口腔科,石河子832000

出　　处：《安徽医科大学学报》2022年第11期1821-1825,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81560442);新疆维吾尔自治区研究生科研创新项目(编号:XJ2020G102)。

摘　　要：目的探讨激酶纤溶酶原激活剂(PLAU)和蛋白激酶B1(AKT1)在口腔鳞癌(OSCC)及正常组织中的表达、预后和两分子在OSCC组织中的相关性。方法采用免疫组化法检测70例OSCC及50例正常组织中PLAU和AKT1的表达水平,分析PLAU和AKT1表达与临床病理特征、预后和两分子在OSCC组织中的相关性,并使用生物信息学数据库进一步验证实验结果。结果PLAU和AKT1在OSCC组织中的表达高于正常组织(P<0.05);Kaplan-Meier分析显示,PLAU和AKT1低表达患者的生存时间长于高表达患者(P<0.05);Spearman秩和相关检验显示,在OSCC组织中,PLAU和AKT1表达有着较强的相关性(r=0.357,P<0.05);GEPIA生物信息学数据库分析结果与实验结果一致。结论PLAU和AKT1在OSCC组织中高表达,且与患者不良预后相关,在OSCC组织中PLAU和AKT1存在相关性。Objective To investigate the expression and prognosis of urokinase plasminogen activator(PLAU)and v-akt murine thymoma viral oncogene homolog 1(AKT1)in oral squamous cell carcinoma(OSCC)and normal tissues and the correlation of PLAU and AKT1 in OSCC tissues.Methods The expression levels of PLAU and AKT1 in 70 cases of oral squamous cell carcinoma and 50 cases of normal tissues were detected by immunohistochemical method,and the correlation between PLAU and AKT1 expression and clinicopathological features and prognosis as well as the correlation between PLAU and AKT1 expression in OSCC tissues was analyzed,and the results were further verified by bioinformatics database.Results The expression of PLAU and AKT1 in OSCC tissues was higher than that in normal tissues(P<0.05),Kaplan-Meier analysis showed that patients with low PLAU and AKT1 expression had longer survival time than those with high AKT1 expression(P<0.05),Spearman rank sum correlation test showed that there was a strong correlation between PLAU and AKT1 expression in OSCC tissues(r=0.357,P<0.05),GEPIA bioinformatics database analysis results are consistent with experimental results.Conclusion PLAU and AKT1 are highly expressed in OSCC tissues and are associated with poor prognosis of patients.There is a correlation between PLAU and AKT1 in OSCC tissues.

关 键 词：口腔鳞癌 PLAU AKT1 免疫组化 预后 

分 类 号：R739.8[医药卫生—肿瘤]