降冰片烯二甲酸酐氨解产物的合成及其抑菌活性  

Synthesis and Anti-bacterial Activities of Ammonolysis Product of Carbic Anhydride with Ammonia Aerivatives

作　　者：李倩倩 易君明 周小琼 唐芳 张家敏 LI Qian-qian;YI Jun-ming;ZHOU Xiao-qiong;TANG Fang;ZHANG Jia-min(College of Biology and Chemistry,Key Laboratory of Chemical Synthesis and Environmental Pollution Control-remediation Technology,Xingyi Normal University for Nationalities,Guizhou Xingyi 562409,China)

机构地区：[1]兴义民族师范学院生物与化学学院,化学合成及环境污染控制和生态修复技术实验室,贵州兴义562409

出　　处：《广州化工》2022年第20期42-47,共6页GuangZhou Chemical Industry

基　　金：贵州省大创项目(No:S202110666093);兴义民族师范学院教授基金项目(No:19XYJS02)。

摘　　要：以降冰片烯二甲酸酐和氨衍生物进行氨解反应,得到新的5个氨解产物,其结构通过^(1)H NMR、^(13)C NMR、MS、IR、元素分析以及单晶X-射线衍射等进行表征,采用96孔板倍比稀释法测定产物对大肠杆菌、肺炎克雷伯菌、金黄色葡萄球菌及枯草芽孢杆菌的抑菌活性。实验结果表明:降冰片烯二酸酐的氨解反应主要受氨基上取代基及其空间位阻的影响,氨解产物有二酰亚胺和邻酰胺基羧酸两种类型,其相邻化合物分子之间主要通过氢键作用,只有在较高浓度范围内才对所测菌种具有抑菌活性。Five novol ammonolysis componds were synthesized from the starting reagent of carbic anhydride and differend amine derivatives through ammonolysis reaction,their structures were characterized by^(1)H NMR,^(13)C NMR,IR,elemental analysis,and single-crystal X-ray diffraction.The inhibitory activity of these compounds against Escherichia coli,Klebsiella pneumoniae,Staphyloccocus aureus and Bacillus subtilis were tested by the 96-well plate dilution doubling method.The experiment result revealed that carbic anhydride ammonolysis reaction affected by the amino substituent group and its steric hindrance,there were two aminolysis products of diimide and o-amide carboxylic acid,the neighbouring aminolysis producted molecules interact mainly through hydrogen bonds.These products had good bacteriostatic activities to all tested bacteria at high concentration rage.

关 键 词：降冰片烯二酸酐 酰胺衍生物 氨解反应 晶体结构 抑菌活性 

分 类 号：O622.6[理学—有机化学]