中枢神经系统孤立性纤维瘤11例的回顾性分析  

Retrospective analysis of 11 cases of solitary fibrous tumors of central nervous system

作　　者：李伟[1] 王业忠 胡滨[1] 姬云翔 柯炎斌[1] 黄观 LI Wei;WANG Yezhong;HU Bin;JI Yunxiang;KE Yanbin;HUANG Guan(Department of Neurosurgery,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China;Department of Medical Records,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China)

机构地区：[1]广州医科大学附属第二医院神经外科,广州510260 [2]广州医科大学附属第二医院病案科,广州510260

出　　处：《广州医药》2022年第6期83-88,共6页Guangzhou Medical Journal

基　　金：广州市卫生健康科技一般引导项目(20221A011081)。

摘　　要：目的 分析中枢神经系统孤立性纤维瘤(SFT)11例患者的临床特点、影像学及病理学表现、手术结果。方法 回顾性分析2013年—2021年于广州医科大学附属第二医院神经外科接受手术并经病理检查证实为中枢神经系统SFT的11例患者的临床资料。结果 11例患者主要症状为头晕、头痛或肢体乏力。MRI:病灶主要表现为T1WI等-低信号,T2WI混杂信号或等-稍高信号。病理组织学:镜下表现为疏密不一的梭形肿瘤细胞呈交替排列。免疫组化:肿瘤细胞主要表现为STAT6阳性、CD34阳性等特点。病灶全切除患者预后较好,病灶次全切除或既往有SFT复发病史患者容易再次复发。结论 中枢神经系统SFT患者MRI T2WI信号有助于诊断,但是最终诊断依靠病理学检查。手术切除是首选的治疗方式。Objective To analyze the clinical features, radiological and pathological manifestations and surgical results of 11 patients with solitary fibrous tumors(SFT) of the central nervous system(CNS). Methods The clinical data of 11 patients with SFT of CNS confirmed by pathological examination in the Neurosurgery Department of the Second Affiliated Hospital of Guangzhou Medical University from 2013 to 2021 were retrospectively analyzed. Results The main symptoms of 11 patients were dizziness, headache or extremity weakness. MRI: the lesions mainly showed iso-low signal on T1 WI,mixed signal or iso-slightly high signal on T2 WI. Histopathological features: microscopically, there were alternating rows of spindle tumor cells with irregular density. Immunohistochemistry showed that the tumor cells were STAT6 positive, CD34 positive, etc. Patients with total resection of the lesion had a better prognosis. Patients with subtotal resection of the lesion or previous history of SFT relapse were prone to relapse. Conclusions MRI T2 WI signals in patients with CNS SFT were helpful for diagnosis, but the final diagnosis depended on pathology. Surgical excision is the preferred treatment.

关 键 词：中枢神经系统 孤立性纤维瘤 回顾性分析 

分 类 号：R739.4[医药卫生—肿瘤]