T型钙通道在心血管疾病中的研究进展  

Progress in role of T-type calcium channel in cardiovascular diseases

作　　者：张弛 赵爽 陈露岚 胡亦清 申程 ZHANG Chi;ZHAO Shuang;CHEN Lu-lan;HU Yi-qing;SHEN Cheng(Affiliated Hospital of Jining Medical University,Jining Medical University,Jining 272067,China;Department of Medical Examination,Shanghai Xuhui District Central Hospital,Shanghai 200031,China;Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai Institute of Cardiovascular Diseases,Shanghai 200032,China;Department of Cardiology,Affiliated Hospital of Jining Medical University,Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases,Jining 272067,China)

机构地区：[1]济宁医学院附属医院,济宁医学院,山东济宁272067 [2]上海市徐汇区中心医院体检科,上海200031 [3]复旦大学附属中山医院心内科,上海市心血管病研究所,上海200032 [4]济宁医学院附属医院心内科,济宁市心血管疾病诊疗重点实验室,山东济宁272067

出　　处：《中国病理生理杂志》2022年第11期2098-2105,共8页Chinese Journal of Pathophysiology

基　　金：济宁医学院贺林院士新医学临床转化工作站科研基金资助项目(No.JYHL2018FMS06)。

摘　　要：电压门控钙通道(voltage-gated calcium channels,VGCC)能够参与调节多种可兴奋性细胞和非兴奋性细胞的生理活动,其中T型钙通道在神经元中产生低阈值钙尖峰并影响动作电位放电模式,在神经递质释放、树突共振现象及基因表达调控中起着关键作用[1]。在血管平滑肌细胞中调节肌源性张力,在内分泌细胞中调节激素的分泌,以及在精子中调节顶体反应。Voltage-gated calciumchannels are controlled byα1 subunit coding.According to the genotype ofα1 subunit,they can be divided into Cav1,Cav2 and Cav3 families.The Cav3 subfamily controls T-type calcium channel and conducts T-type Ca^(2+)current.Compared with other Ca^(2+)currents,T-type Ca^(2+)current has the characteristics of rapid voltage-dependent deactivation.In sinoatrial node,T-type calcium channel is an important part of conducting pacing current.T-type calcium channel is regulated by hormones such as angiotensin,adrenaline and aldosterone.It plays an important role in cardiovascular diseases such as congenital heart block,myocardial hypertrophy and arrhythmia,and regulates the contraction and relaxation of blood vessels.This article reviews the structure and function of T-type calcium channel and its role in cardiovascular diseases.

关 键 词：电压门控钙通道 T型钙通道 心血管疾病 

分 类 号：R363[医药卫生—病理学] R541[医药卫生—基础医学]