肿瘤心脏病学动物模型的研究进展  

Research progress on animal models of cardio-oncology

作　　者：张钰[1,2] 孟婷婷 田鹏 郑燕[1,2,3] 苏国海 ZHANG Yu;MENG Tingting;TIAN Peng;ZHENG Yan;SU Guohai(Shandong University,Jinan 250013,China;Jinan Central Hospital,Jinan 250013;Research Center of Translational Medicine,Central Hospital Affiliated to Shandong First Medical University,Jinan 250013)

机构地区：[1]山东大学,济南250013 [2]济南市中心医院,济南250013 [3]专科转化研究中心,山东第一医科大学附属中心医院,济南250013

出　　处：《中国比较医学杂志》2022年第10期115-122,共8页Chinese Journal of Comparative Medicine

基　　金：国家科技重大专项(2020ZX09201025);山东省自然科学基金面上项目(ZR2017MH050)。

摘　　要：肿瘤心脏病学是涉及肿瘤学和心血管病学的新型交叉学科,随着肿瘤治疗策略的突飞猛进发展,患者生存期得以延长的同时,治疗的副作用特别是心血管毒性受到越来越多的关注。肿瘤心脏病学动物模型的应用有助于了解心血管毒性的发病机制,寻找有效的心血管保护措施,防止发生不可逆的损伤。目前非荷瘤啮齿类动物的肿瘤心脏病学模型应用较为广泛,但不同研究中采用的建模方式差别较大。本文收集整理了近年来化疗、分子靶向治疗和放疗等抗肿瘤方案所建立的肿瘤心脏病学的动物模型,总结了不同动物模型的优缺点和建模方法,并从模型的选择、用药剂量和检测指标等方面进行综述,对建立合适的动物模型提出了建议,助力临床肿瘤心脏病学的发展。Cardio-oncology is a new interdisciplinary subject involving oncology and cardiovascular disease.With the rapid development of tumor treatment strategies,the survival of patients has been prolonged,and the side effects of treatments,especially cardiovascular toxicity,have received increasing attention.The establishment of an animal model of cardio-oncology is helpful to understand the pathogenesis of cardiovascular toxicity and take cardioprotective measures to prevent irreversible damage.Currently,non-tumor-bearing rodents are used in experiments.They are widely used,but there are few studies on animal modeling method.In this review,animal models of cardio-oncology established by anti-tumor treatments,such as chemotherapy,molecular targeted therapy,and radiotherapy,in recent years were collected and sorted,and the advantages and disadvantages of various animal models and modeling method were summarized.This article reviews the aspects of the developing clinical cardio-oncology and provides insights for the development of clinical cardio-oncology.

关 键 词：肿瘤心脏病学 心血管毒性 动物模型 

分 类 号：R-33[医药卫生]