结直肠腺癌肝转移灶中差分化肿瘤细胞群的临床病理意义  

Clinicopathological Significance of Poorly Differentiated Clusters in Liver Metastatic Lesions of Colorectal Carcinoma

作　　者：彭辉 张志发[1] 伍颖君 张潇涵 朱贤强 秦海丽 PENG Hui;ZHANG Zhifa;WU Yingjun;ZHANG Xiaohan;ZHU Xianqiang;QIN Haili(Department of Pathology,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,China;Department of Pathology,Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine,Zhuhai 519000,China)

机构地区：[1]广州中医药大学第二附属医院/广东省中医院病理科,广州510120 [2]广东省中医院珠海医院病理科,珠海519000

出　　处：《肿瘤防治研究》2022年第11期1165-1167,共3页Cancer Research on Prevention and Treatment

基　　金：珠海市医学科研项目(ZH2401330210005PWC)。

摘　　要：目的探讨肝转移灶中差分化肿瘤细胞群(PDC)的临床病理意义,分析肝转移灶与肠原发灶中PDC分级的相关性。方法回顾性分析72例结直肠癌伴有肝转移的配对病例。同时对结肠癌原发灶和肝转移灶中PDC进行判读,分析肝转移灶中PDC分级与各临床病理参数之间的关系及原发灶与转移灶中PDC分级的相关性。PDC的判读方法采用Ueno标准。结果72例结直肠癌肝转移灶中,PDC分级G1、G2、G3的例数分别为28、24、20。转移灶的PDC分级与转移灶的肿瘤芽、原发灶的PDC分级具有正相关,而与转移灶大小、数目、原发灶部位、级别、浸润深度、淋巴结转移情况、脉管侵犯及肿瘤芽无显著相关。结论结直肠腺癌肝转移瘤与原发性结直肠腺癌的PDC分级存在正相关,评估原发灶PDC分级或可为肝转移风险提供参考。Objective To investigate the clinicopathological significance of PDC in liver metastases and analyze the correlation of PDC between liver metastases and primary lesions.Methods Retrospective analysis of 72 matched cases of colorectal cancer with liver metastases was performed.The PDC in primary tumor and liver metastatic lesion was interpreted synchronously,and then the relationship between PDC in liver metastasis and clinicopathological parameters was analyzed based on the correlation of PDC between primary and metastatic lesions.In addition,PDC were interpreted in accordance with Uenos’standard.Results Among the 72 cases of liver metastasis of colorectal cancer,the number of G1,G2,and G3 graded by PDC was 28,24,and 20,respectively.The PDC in liver metastatic lesion was correlated with tumor budding in liver metastatic lesion and PDC grade of primary lesion.No significant correlation with the size and number of liver metastatic lesion,the site,WHO grade,depth of invasion,lymph node metastasis,vascular invasion or tumor budding of the primary lesion was observed.Conclusion A positive correlation is found between liver metastasis of colorectal adenocarcinoma and PDC grade of primary tumor.Evaluating the PDC grade of primary tumor may provide a reference for the risk of liver metastasis.

关 键 词：结直肠腺癌肝转移 差分化肿瘤细胞群 肿瘤芽 

分 类 号：R735.3[医药卫生—肿瘤]