Auer小体对初诊非M3型急性髓细胞白血病患者预后的影响  

Effects of Auer Bodies on the Prognosis of Newly DiagnosedNon-M3 Acute Myeloid Leukemia Patients

作　　者：江娟[1] 江源 申虹 祝文娟[1] JIANG Juan;JIANG Yuan;SHEN Hong(Chizhou People's Hospital,Anhui Chizhou 247100,China)

机构地区：[1]安徽省池州市人民医院血液内科,安徽池州247100

出　　处：《河北医学》2022年第11期1841-1845,共5页Hebei Medicine

基　　金：安徽省卫生健康委科研项目,(编号:AHWJ2021b106)。

摘　　要：目的:分析Auer小体对初诊非M3型急性髓细胞白血病(AML)患者预后的影响。方法:回顾性选取2017年1月至2022年1月池州市人民医院124例初诊非M3型AML患者作为研究对象,依据骨髓原始细胞有无Auer小体将患者分为Auer小体阳性组与Auer小体阴性组,记录患者的年龄、性别、疾病危险度分级、实验室指标、诱导缓解成功率等临床特征,随访患者临床结局及预后情况,绘制Kaplan-Meier生存曲线,对比两组患者总生存期(OS)。结果:124例非M3型AML患者中,54例为Auer小体阳性,70例Auer小体阴性。两组患者在年龄、性别构成比、病史、发热、出血、疼痛、贫血、疾病危险度分级方面比较,差异无统计学意义(P>0.05),在合并心血管疾病及消化系统疾病占比方面比较,差异有统计学意义(P<0.05);两组患者实验室指标WBC、PLT、Hb、LDH水平差异无统计学意义(P>0.05),融合基因占比情况比较,差异无统计学意义(P>0.05);随访患者预后,结果显示两组完全缓解率、复发率差异无统计学意义(P>0.05),但Auer小体阳性组死亡率明显低于Auer小体阴性组,差异有统计学意义(P<0.05);Kaplan-Meier生存曲线显示,两组患者无进展生存期(DFS)差异无统计学意义(P>0.05),但Auer小体阳性组OS明显高于Auer小体阴性组,差异有统计学意义(P<0.05)。结论:Auer小体与初诊非M3型AML患者预后密切相关,Auer小体阳性者少有心血管疾病,易合并消化系统症状,死亡率低,总生存期及预后优于Auer小体阴性者,应予以重视。Objective:To analyze the effect of Auer bodies on the prognosis of newly diagnosed non-M3 acute myeloid leukemia(AML)patients.Methods:From January 2017 to January 2022,124 newly diagnosed non-M3 AML patients in Chizhou People's Hospital were retrospectively selected as the research subjects,and the patients were divided into Auer body positive group and Auer body negative group according to the presence or absence of Auer bodies in bone marrow blast cells.In the negative group,the clinical characteristics such as age,gender,disease risk classification,laboratory indicators,and success rate of induction of remission were recorded.The clinical outcome and prognosis of the patients were followed up,and the Kaplan-Meier survival curve was plotted to compare the overall survival(OS)of the two groups of patients.Results:Among the 124 non-M3 AML patients,54 were Auer body positive and 70 were Auer body negative.There was no difference between the two groups in age,sex,medical history,fever,bleeding,pain,anemia,and disease risk classification.There was statistical significance(P>0.05),and there was a statistically significant difference in the proportion of combined cardiovascular disease and digestive system disease(P<0.05);there was no significant difference in laboratory indicators WBC,PLT,Hb,and LDH between the two groups(P>0.05).There was no significant difference in the proportion of fusion genes(P>0.05).There was no significant difference in the complete remission rate and recurrence rate between the two groups,P>0.05,but the mortality rate of the Auer body positive group was lower than that of the Auer body negative group,and the difference was statistically significant(P<0.05);Kaplan-Meier survival curves showed no statistically significant difference in progression-free survival(DFS)between the two groups(P>0.05),but the OS of the Auer body positive group was higher than that of the Auer body negative group,and the difference was statistically significant(P<0.05).Conclusion:Auer bodies are closely related to th

关 键 词：初诊非M3型急性髓细胞白血病 AUER小体 预后 Kaplan-Meier生存曲线 

分 类 号：R733.71[医药卫生—肿瘤]