非编码RNA在消化系统肿瘤中的作用  

Role of non-coding RNA in digestive system tumors

作　　者：苏琦 SU Qi(Hunan Key Laboratory of Cancer Cellular and Molecular Pathology,Cancer Research Institute,Hengyang Medical College,University of South China,Hengyang 421001,Hunan,China)

机构地区：[1]湖南省肿瘤细胞与分子病理学重点实验室,南华大学衡阳医学院肿瘤研究所,湖南省衡阳市421001

出　　处：《中南医学科学杂志》2022年第6期781-784,共4页Medical Science Journal of Central South China

基　　金：国家自然科学基金(81374013,81641112)。

摘　　要：结直肠癌、胃癌与肝癌等消化系统肿瘤的发病率与死亡率居中国肿瘤的前5位,这些消化道肿瘤早期诊断困难,常规手术和化疗效果较差且存在抗药性,其5年生存率低,严重危害人民的生命健康。因此,探讨其侵袭转移机制与治疗靶点至关重要。目前,非编码RNA在肿瘤中的作用已经成为研究热点,本专栏重点概述非编码RNA在结直肠癌、胃癌与肝癌中的作用,希望为肿瘤发生与治疗提供新视角和潜在靶点。The incidence and mortality of digestive system tumors such as colorectal cancer,gastric cancer and liver cancer are among the top 5 tumors in China.Due to the difficulties in early diagnosis,poor efficacy of conventional surgery and chemotherapy,and drug resistance,the 5-year survival rate is low,which seriously endangers people s life and health.Therefore,it is very important to explore the mechanism of invasion and metastasis and therapeutic targets.At present,the role of non-coding RNA in cancer has become a research hotspot.This column summarizes the role of non-coding RNA in colorectal cancer,gastric cancer and liver cancer in combination with the work of relevant experts,hoping to pro-vide a new perspective and potential targets for tumorigenesis and treatment.

关 键 词：消化系统肿瘤 非编码RNA 侵袭转移机制 靶点 

分 类 号：R735.2[医药卫生—肿瘤]