热休克因子1在肿瘤侵袭与治疗中的研究进展  

Research progress of heat shock factor 1 in tumor invasion and treatment

作　　者：张琳[1] 王桂春 尹萍 宋阳 路中[2] ZHANG Lin;WANG Guichun;YIN Ping;SONG Yang;LU Zhong(Weifang Medical University,Weifang 261000,Shandong,China;Department of Oncology,the Affiliated Hospital of Weifang Medical University,Weifang 261000,Shandong,China)

机构地区：[1]潍坊医学院,山东省潍坊市261000 [2]潍坊医学院附属医院肿瘤科,山东省潍坊市261000

出　　处：《中南医学科学杂志》2022年第6期949-952,共4页Medical Science Journal of Central South China

基　　金：北京医卫健康公益基金会医学科学研究基金(YWJKJJHKYJJ-E1160A)。

摘　　要：热休克因子1(HSF1)是调控真核细胞热休克基因转录的关键因子,在应激和正常生理条件下发挥重要作用。HSF1通过多种途径促进肿瘤的发生与发展,本文就HSF1的结构、肿瘤对HSF1的调控、HSF1在肿瘤中的作用及HSF1靶向治疗进行综述。Heat shock factor 1(HSF1)is a key factor regulating the transcription of heat shock genes in eukaryotic cells,which plays an important role in stress and normal physiological conditions.HSF1 promotes tumor genesis and development through various pathways.In this paper,the structure of HSF1,the regulation of HSF1 by tumors,the role of HSF1 in tumors and HSF1 targeted therapy are reviewed.

关 键 词：热休克因子1 肿瘤 耐药 靶向治疗 

分 类 号：R73-36[医药卫生—肿瘤]