TACE介入治疗联合放射性粒子对原发性肝癌患者CT灌注参数和免疫功能的影响  

Effects of TACE Interventional Therapy Combined with Radioactive Particles on CT Perfusion Parameters and Immune Function in Patients with Primary Liver Cancer

作　　者：陈龙 鲍乐[1] 李鹏飞[1] 王友彬[1] 梁爽 CHEN Long;BAO Le;LI Pengfei;WANG Youbin;LIANG Shuang(Xuzhou Cancer Hospital,Xuzhou 221000,China;不详)

机构地区：[1]徐州市肿瘤医院,江苏徐州221000

出　　处：《中外医学研究》2022年第31期54-58,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究经导管动脉栓塞化疗(transcatheter arterial chemoembolization,TACE)联合放射性粒子对原发性肝癌患者CT灌注参数和免疫功能指标的影响。方法:选择2019年1月-2021年1月徐州市肿瘤医院收治的80例原发性肝癌患者作为研究对象,采用随机数字表法分为试验组(n=40)和对照组(n=40)。对照组采用TACE介入治疗,试验组同时采用放射性粒子植入治疗。比较两组治疗效果、CT灌注参数、免疫功能因子水平。结果:试验组的疾病控制率高于对照组,差异有统计学意义(P<0.05);试验组治疗后的血流量、血容量、表面通透性、平均通过时间、肝动脉分数低于对照组,差异有统计学意义(P<0.05);试验组治疗后的CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。结论:TACE联合放射性粒子治疗原发性肝癌患者能有效提升患者疾病治疗效果,患者各项CT灌注参数均显著降低,且免疫功能得到有效改善,值得临床推广。Objective:To study the effects of transcatheter arterial chemoembolization(TACE)combined with radioactive particles on CT perfusion parameters and immune function indexes in patients with primary liver cancer.Method:Eighty patients with primary liver cancer admitted to Xuzhou Cancer Hospital from January 2019 to January 2021 were selected as the study subjects,and were divided into experimental group(n=40)and control group(n=40)by random number table.The control group was treated with TACE intervention,and the experimental group was treated with radioactive particle implantation at the same time.The therapeutic effect,CT perfusion parameters and immune function factors were compared between the two groups.Result:The disease control rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The blood flow,blood volume,surface permeability,mean transit time and hepatic artery fraction of the experimental group after treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CD4^(+),CD4^(+)/CD8^(+),NK cells in the experimental group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:TACE combined with radioactive particles in the treatment of patients with primary liver cancer can effectively improve the treatment effect of patients,the CT perfusion parameters of patients are significantly reduced and the immune function is effectively improved,which is worthy of clinical promotion.

关 键 词：原发性肝癌 动脉灌注化疗栓塞术 放射性粒子 CT灌注参数 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤] R730.44[医药卫生—临床医学]