中医药调节溃疡性结肠炎常见证候肠道菌群的研究进展  

Research Progress on Traditional Chinese Medicine in Regulating Intestinal Flora in Ulcerative Colitis of Common Syndromes

作　　者：张玉雯 王佳佳[1] 巴寅颖[1] 王文娟[1] 迟莉[1] 游超瑞 王天芳 ZHANG Yuwen;WANG Jiajia;BA Yinying;WANG Wenjuan;CHI Li;YOU Chaorui;WANG Tianfang(School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]首都医科大学中医药学院,北京100069 [2]北京中医药大学中医学院,北京100029

出　　处：《世界中医药》2022年第20期2953-2958,共6页World Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82104765,81703670);北京市中医药“薪火传承3+3工程”冯建春名医传承工作站(2015-SZ-C-58)。

摘　　要：溃疡性结肠炎作为难治性肠道疾病之一,其病因尚未完全明确,研究证实肠道菌群失调与溃疡性结肠炎发病联系密切。中医药治疗溃疡性结肠炎体现了整体调节、辨证论治的特色与优势,中医药可通过改善菌群结构、调节菌群数量、调整肠道菌群稳态治疗溃疡性结肠炎,且溃疡性结肠炎不同中医证候的肠道菌群存在着明显差异。现通过分析溃疡性结肠炎常见证候(大肠湿热证、脾虚湿蕴证、脾肾阳虚证、脾气亏虚证、肝郁脾虚证、寒热错杂证、热毒炽盛证)肠道菌群的特点及中医药调节溃疡性结肠炎常见证候肠道菌群的研究现状,以期为溃疡性结肠炎的微观辨证及中医药治疗溃疡性结肠炎的作用机制研究提供依据。The etiology of ulcerative colitis(UC),as one of the refractory intestinal diseases, has not been fully illustrated.However, it has been confirmed that the imbalance of intestinal flora is closely related to UC.Traditional Chinese medicine(TCM) in the treatment of UC reflects the characteristics and advantages of overall regulation and treatment based on syndrome differentiation.UC can be treated by TCM by improving the structure, regulating the number, and recovering the homeostasis of intestinal flora.In addition, there are certain differences in intestinal flora in the context of UC of different TCM syndromes.The present study analyzed the characteristics of intestinal flora in UC of common TCM syndromes(dampness-heat in large intestine syndrome, spleen deficiency with dampness accumulation syndrome, yang deficiency in spleen and kidney syndrome, spleen qi deficiency syndrome, liver qi stagnation and spleen deficiency syndrome, intermingled heat and cold syndrome, and blazing heat-toxin syndrome) and reviewed the research progress on TCM in regulating intestinal flora in UC,aiming to provide a basis for the microscopic syndrome differentiation of UC and the mechanism research of TCM in the treatment of UC.

关 键 词：溃疡性结肠炎 肠道菌群 辨证论治 证候 中医药 肠道菌群失调 机制 炎症性肠病 

分 类 号：R574.62[医药卫生—消化系统] R259[医药卫生—内科学]