Surveillance tools for detection of recurrent nasopharyngeal carcinoma: An evidence-based review and recommendations  

作　　者：Andrew Thamboo Kim H.Tran Annette X.Ye Issraa Shoucair Basel Jabarin Eitan Prisman Cathie Garnis 

机构地区：[1]St.Paul's Sinus Centre,Otolaryngology Head and Neck Surgery,1081Burrard St,Vancouver,V6Z 1Y6,BC,Canada [2]Department of Biomedical Physiology and Kinesiology,SimonFraserUniversity,8888 University Dr,Burnaby,V5A1S6,BC,Canada [3]The University of British Columbia Faculty of Medicine,MDProgram,317-2194Health SciencesMall,Vancouver,V6T1Z3,BC,Canada [4]British Columbia Cancer Research Centre,Cancer Genetics and Developmental Biology,675 W 10th Ave,Vancouver,V5Z 1L3,BC,Canada [5]VancouverGeneral Hospital,Otolaryngology HeadandNeckSurgery,899W12thAve,Vancouver,V5Z 1M9,BC,Canada

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2022年第3期187-204,共18页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Objective: Nasopharyngeal carcinomas (NPC) are tumors arising from epithelium of the nasopharynx. The 5-year survival rate of primary NPC is 80% with significant risks of recurrence. The objective here is to provide an evidence-based systemic review of the diagnostic value of different modalities in detecting local, regional, and distal recurrent NPC, as well as the associated costs with these modalities.Methods: MEDLINE, EMBASE, and the Cochrane review database were queried. Two hundred and twenty-three abstracts were generated using the inclusion criteria: patients >18 years of age;histopathological reference standard;and modalities pertaining to imaging or microbiology.Results: Twenty-four manuscripts fulfilled the inclusion criteria and 5 surveillance tools identified: endoscopy, MR, FDG-PET, Tc-99m MIBI and201TI SPECT, and EBV DNA.Conclusions: For local surveillance, endoscopy is the gold standard recommendation, with increased efficacy if Narrow Band Imaging or contact endoscopy are utilized. MRI and FDG-PET is also recommended to help with local to distal spread;however, Tc-99m MIBI and201TI SPECT are options as well. EBV DNA is recommended as a cheap and accessible adjunct surveillance tool if an available as an option.

关 键 词：EBV DNA FDG-PET Imaging MR ENDOSCOPY Recurrent Nasopharyngeal Carcinoma 

分 类 号：R739.63[医药卫生—肿瘤]