基于信号通路探讨中医药促进缺血性脑卒中血管新生机制研究进展  

Research Progress on Mechanism of Traditional Chinese Medicine in Promoting Angiogenesis of Ischemic Stroke Based on Signal Pathway

作　　者：付彩红 宋运恒 刘宏伟 杨阳 张虎 FU Caihong;SONG Yunheng;LIU Hongwei;YANG Yang;ZHANG Hu(Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China;Civil Aviation General Hospital,Beijing 100123,China)

机构地区：[1]北京中医医院顺义医院,北京101300 [2]民航总医院,北京100123

出　　处：《辽宁中医药大学学报》2022年第10期78-84,共7页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年项目(81804090);北京市科技计划课题(Z171100001017150);北京中医医院顺义医院院级自然基金课题(SYYJ-201908)。

摘　　要：现代研究表明血管新生是缺血性脑卒中神经功能恢复的重要结构基础,中医药在促进血管新生过程中发挥多靶点、多途径、多环节的调节和促进作用,有望成为治疗性血管新生的一种潜在有效方法,但其效应机制尚不明确。近年来,基于信号通路研究血管新生机制及有效方法的干预机制是目前脑卒中重塑领域的热点问题。该文通过阐释血管新生的中医内涵以及综述中医药对参与缺血性脑卒中后血管新生相关通路调节作用的研究进展,以期为中医药促进卒中后神经功能恢复的基础研究提供方法和借鉴。Modern studies have shown that angiogenesis is an important structural basis for neurological function recovery of ischemic stroke.Traditional Chinese medicine plays a role of multi-target,multipathway and multi-link regulation and promotion in the process of promoting angiogenesis,which has been a potentially effective method for therapeutic angiogenesis,but the mechanism of its effect remains unclear.In recent years,the research on the mechanism and effective intervention of angiogenesis based on signaling pathway has become a hot issue in the field of stroke remodeling.The connotation of traditional Chinese medicine of angiogenesis and the research progress of the regulating effect of traditional Chinese medicine on signal pathways related angiogenesis of ischemic stroke were summed up in this paper,in order to provide new methods for basic research on the promotion of neurological function recovery after stroke by traditional Chinese medicine.

关 键 词：信号通路 中药 针刺 脑血管病 血管再生 

分 类 号：R743.31[医药卫生—神经病学与精神病学]