探讨调中益气汤治疗胃食管反流病作用机制及研究进展  

Exploration of the Mechanism and Research Progress of Tiaozhong Yiqi Decoction(调中益气汤)in the Treatment of Gastroesophageal Reflux Disease

作　　者：蒙华莹 刘建来 韦熔煌 梁雅琳 秦艳琴 谢胜[2] MENG Huaying;LIU Jianlai;WEI Ronghuang;LIANG Yalin;QIN Yanqin;XIE Sheng(Guangxi University of Traditional Chinese Medicine,Nanning 530000,Guangxi,China;The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530022,Guangxi,China)

机构地区：[1]广西中医药大学,广西南宁530000 [2]广西中医药大学第一附属医院,广西南宁530022

出　　处：《辽宁中医药大学学报》2022年第10期120-123,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药管理局资助项目(2019XZZX-XH003);广西中医脾胃病临床医学研究中心资助项目(桂科AD19245168)。

摘　　要：近年来文献研究显示,胃食管反流病的发病机制与炎症免疫相关,食管黏膜下层炎症反应在疾病的发生、发展中起到关键作用,因此可以炎症免疫应答通路为切入点,通过控制炎症以达到治疗胃食管反流病的目的。调中益气汤出自李东垣《脾胃论》,药理学研究显示方药中所含有的多种成分具有一定的抗炎作用,而且药物之间可能存在相互影响,通过作用于多器官、多靶点从而发挥良好疗效。许多医家认为胃食管反流病的病机为脾胃运化失调,气机逆乱,而调中益气汤可调理脾胃,促使中焦气机升降恢复正常,在治疗胃食管反流病中有一定效果。该文主要从胃食管反流病的西医发病机制、中医病机、调中益气汤药理研究等方面论述,以期为中医药治疗胃食管反流病提供理论依据。According to recent literature studies,it is believed that the pathogenesis of gastroesophageal reflux disease is related to inflammation and immunity,and the inflammatory response in the submucosa of the esophagus plays a key role in the occurrence and development of the disease.Therefore,the objective of gastroesophageal reflux disease can be achieved by controlling inflammation from the inflammatory immune response pathway as the entry point.Tiaozhong Yiqi Decoction(调中益气汤)mentioned in this literature comes from LI Dongyuan’s Spleen and Stomach Theory.The various ingredients contained in the prescriptions have certain anti-inflammatory effects in pharmacological studies,and there may be mutual influence between drugs,so as to play a good effect by acting on multiple organs and multiple targets.Many doctors believe that the pathogenesis of gastroesophageal reflux disease is the disorder of the movement of spleen and stomach,Qi machine inverse disorder,and Tiaozhong Yiqi Decoction can regulate the spleen and stomach,promote the rise and fall of middle-Jiao movement of Qi machine to return to normal,in the treatment of gastroesophageal reflux disease has a certain effect.This article mainly discusses the pathogenesis of gastroesophageal reflux disease in Western medicine,pathogenesis of traditional Chinese medicine and pharmacological study of Tiaozhong Yiqi Decoction,so as to provide theoretical basis for the treatment of gastroesophageal reflux disease with traditional Chinese medicine.

关 键 词：胃食管反流病 炎症 中医病机 调中益气汤 药理 综述 

分 类 号：R571[医药卫生—消化系统]