结直肠癌和结直肠息肉患者幽门螺杆菌感染及合并胃息肉情况分析  

Helicobacter pylori infection and gastric polyps in patients with colorectal cancer and colorectal polyps

作　　者：王秋红[1] 杜桂清[1] 邓桂霞[1] 邵林娟 Wang Qiuhong;Du Guiqing;Deng Guixia;Shao Linjuan(Department of Pathology,General Hospital of Beijing Jingmei Group,Beijing 102300,China)

机构地区：[1]北京京煤集团总医院病理科,北京102300

出　　处：《肿瘤研究与临床》2022年第9期670-673,共4页Cancer Research and Clinic

摘　　要：目的探讨幽门螺杆菌(Hp)感染及合并胃息肉对结直肠病变的影响。方法回顾性分析北京京煤集团总医院2020年1月至2021年6月胃镜及肠镜检查发现的2 034例结直肠息肉患者及118例结直肠癌患者的临床资料, 以同期检查未发现结直肠息肉的178例患者作为对照, 分析不同年龄、性别、病理类型患者中Hp感染及合并胃息肉的情况。结果结直肠癌组患者年龄及男性患者比例均高于对照组及结直肠息肉组(均P<0.05)。对照组、结直肠息肉组及结直肠癌组Hp感染率分别为20.8%(37/178)、23.0%(467/2 034)、27.1%(32/118), 差异均无统计学意义(均P>0.05)。2 034例结直肠息肉中, 炎症性息肉612例, 增生性息肉371例, 腺瘤性息肉1 051例, 3组结直肠息肉组Hp感染率分别为24.5%(150/612)、22.4%(83/371)、22.3%(234/1 051), 3组患者胃息肉发生率分别为34.6%(212/612)、38.3%(142/371)、39.3%(413/1 051), 差异均无统计学意义(均P>0.05);3种结直肠息肉组年龄与对照组及结直肠癌组两两比较, 除炎症性息肉与增生性息肉组外, 其余差异均有统计学意义(均P<0.05)。3种结直肠息肉合并胃息肉患者中女性所占比例均高于男性, 差异均有统计学意义(均P<0.05)。对照组、不同类型结直肠息肉组及结直肠癌组中Hp阳性患者年龄均低于阴性患者, 但仅腺瘤性息肉组差异有统计学意义(P=0.002);3种结直肠息肉合并胃息肉患者年龄均大于未合并胃息肉患者, 结直肠癌合并胃息肉患者年龄小于未合并胃息肉患者, 差异均有统计学意义(均P<0.05)。Hp感染、合并胃息肉与结直肠息肉及结直肠癌均无相关性(均P>0.05)。结论 Hp感染可能对结直肠腺瘤性息肉早期发生起促进作用;尚不能证实胃息肉与结直肠息肉发生风险相关;女性结直肠息肉患者发生胃息肉的风险更高。Objective To investigate the effect of helicobacter pylori(Hp)infection and gastric polyps on colorectal cancer lesions.Methods The clinical data of 2034 patients with colorectal polyps and 118 patients with colorectal cancer detected by gastroscopy and colonoscopy examination in General Hospital of Beijing Jingmei Group from January 2020 to June 2021 were retrospectively analyzed.A total of 178 patients without colorectal polyps in the same period were treated as controls to analyze Hp infection and gastric polyps in patients with different ages,genders and pathological types.Results The age and the proportion of male patients in colorectal cancer group were higher than those in the control group and colorectal polyps group(all P<0.05).The Hp infection rates of the control group,colorectal polyps group and colorectal cancer group were 20.8%(37/178),23.0%(467/2034)and 27.1%(32/118),respectively,and the differences were statistically significant(all P>0.05).Among 2034 cases of colorectal polyps,there were 612 cases of inflammatory polyps,371 cases of proliferative polyps and 1051 cases of adenomatous polyps.The infection rates of Hp in the three kinds of colorectal polyps were 24.5%(150/612),22.4%(83/371)and 22.3%(234/1051),respectively.The incidence of patients with gastric polyps in the 3 groups was 34.6%(212/612),38.3%(142/371)and 39.3%(413/1051),respectively,and the differences were statistically significant(all P>0.05).The age of the three colorectal polyps groups was significantly different from that of the control group and colorectal cancer group(all P<0.05)except for inflammatory polyps and proliferative polyps groups.The proportion of female in three kinds of colorectal polyps combined with gastric polyps was higher than that in male patients(all P<0.05).The age of Hp positive patients in the control group,different types of colorectal polyps groups and colorectal cancer group was lower than that in negative patients,but there was a statistically significant difference only in adenomatous polyps group(P=

关 键 词：结直肠肿瘤 结直肠息肉 幽门螺杆菌 胃息肉 

分 类 号：R735.34[医药卫生—肿瘤]