默克尔细胞癌发病机制的研究进展  

Progress of the pathogenesis in Merkel cell carcinoma

作　　者：薛少军 张梦圆 王子国 周军涛[1] 李险峰[1] Xue Shaojun;Zhang Mengyuan;Wang Ziguo;Zhou Juntao;Li Xianfeng(Department of Radiotherapy,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Plastic Surgery,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院放疗科,太原030001 [2]山西医科大学第一医院整形美容烧伤外科,太原030001

出　　处：《肿瘤研究与临床》2022年第9期710-713,共4页Cancer Research and Clinic

摘　　要：默克尔细胞癌(MCC)是一种罕见的原发性皮肤神经内分泌肿瘤, 因其超微结构和免疫表型与皮肤中的默克尔细胞相似而得名。MCC与Merkel细胞多瘤病毒(MCPyV)的整合可能驱动肿瘤发生, 或由于紫外线诱导DNA损伤的体细胞突变而发展为MCC。目前MCC的发病机制尚不清楚。文章就MCC发病机制的研究进展进行阐述, 以期为后续研究提供理论指导。Merkel cell carcinoma(MCC)is a rare primary neuroendocrine carcinoma of the skin,which is named for its ultrastructure and immunophenotype similar to Merkel cells in the skin.It has been found that the integration of MCC with the oncogenic Merkel cell polyomavirus(MCPyV)may drive tumorigenesis or cause somatic mutations to the development of MCC because of ultraviolet ray-induced DNA damage.However,the pathogenesis of MCC is still unclear.This article introduces the current research progress of the pathogenesis of MCC,hoping to provide theoretical guidance for follow-up researches.

关 键 词：神经内分泌瘤 默克尔细胞 免疫组织化学 研究 

分 类 号：R739.5[医药卫生—肿瘤]