辽宁省3市居民卵巢癌10年生存率及影响因素分析  

The 10-year survival rate of ovarian cancer and its influencing factors in three cities of Liaoning province

作　　者：穆慧娟[1] 王丽娟[2] 安晓霞[3] 吕艺[4] 张蕊[1] 李爽[1] 于飞[5] 潘国伟 礼彦侠[1] MU Hui-Juan;WANG Li-Juan;AN Xiao-Xia(Liaoning Center for Disease Control and Prevention,Shenyang,Liaoning 110005,China)

机构地区：[1]辽宁省疾病预防控制中心慢病所,辽宁沈阳110005 [2]鞍山市疾病预防控制中心慢病所,辽宁鞍山114009 [3]本溪市疾病预防控制中心慢病所,辽宁本溪117000 [4]沈阳市疾病预防控制中心慢病所,辽宁沈阳110000 [5]中国医科大学公共卫生学院,辽宁沈阳110122

出　　处：《中国妇幼保健》2022年第20期3803-3807,共5页Maternal and Child Health Care of China

基　　金：辽宁省“兴辽英才计划”项目(XLYC1802131)。

摘　　要：目的分析辽宁省3市居民卵巢癌10年生存状况及其影响因素。方法辽宁省3市2000—2002年肿瘤发病报告数据库随机抽取的卵巢癌患者进行主动随访,获得患者诊疗和生存状况。采用寿命表法计算观察生存率(OSR),应用EdererⅡ方法计算相对生存率(RSR)。多因素Cox模型分析生存影响因素。结果辽宁省3市居民卵巢癌10年OSR、RSR及中位生存期(T_(50))分别为23.40%、25.96%、33.16个月。Ⅰ期和Ⅱ期患者OSR、RSR及T_(50)(51.79%、54.85%及98.40个月;33.33%、36.81%及54.00个月)分别显著高于Ⅲ期(10.39%、12.34%及33.86个月)和Ⅳ期(10.00%、12.47%及19.71个月),差异均有统计学意义(Z_(OSR)=5.50,P<0.05;Z_(RSR)=5.19,P<0.05;χ^(2)=28.29,P<0.05;Z_(OSR)=5.59,P<0.05;Z_(RSR)=5.16,P<0.05;χ^(2)=41.13,P<0.05);手术治疗患者10年OSR、RSR及T_(50)(26.54%、29.45%及38.20个月)显著高于未接受手术治疗患者(7.69%、9.18%及11.14个月);0~49岁组10年OSR(35.09%)和T_(50)(43.71个月)显著高于50~64岁组和≥65岁组(21.25%和9.52%;22.59个月和24.00个月),其RSR(35.70%)显著高于≥65岁组(14.15%);50~64岁组10年OSR和T_(50)显著高于≥65岁组。多因素分析结果显示,诊断分期、治疗方式及年龄对卵巢癌10年RSR有显著影响。结论辽宁省3市居民卵巢癌10年生存率低于发达国家同期水平,早诊率和规范性诊疗率低可能是主要原因。Objective To analyze the 10-year survival status of ovarian cancer and its influencing factors among residents of 3 cities in Liaoning Province.Methods Ovarian cancer patients randomly selected from the tumor incidence report database from 2000 to 2002 in 3 cities in Liaoning Province were actively followed up to obtain the diagnosis and treatment and survival status of the patients.The observed survival rate(OSR)was calculated by the life table method,and the relative survival rate(RSR)was calculated by the EdererⅡmethod.Multivariate Cox model was used to analyze the influencing factors of survival.Results The 10-year OSR,RSR and median survival time(T50)of ovarian cancer residents in 3 cities in Liaoning Province were 23.40%,25.96%and 33.16 months,respectively.The OSR,RSR and T50 of stageⅠandⅡcases(51.79%,54.85%and 98.40 months;33.33%,36.81%and 54.00 months)were significantly higher than those of stageⅢ(10.39%,12.34%and 33.86 months),respectively.and stageⅣ(10.00%,12.47%and 19.71 months),the difference was statistically significant(Z_(OSR)=5.50,P<0.05;Z_(RSR)=5.19,P<0.05;χ^(2)=28.29,P<0.05;Z_(OSR)=5.59,P<0.05;Z_(RSR)=5.16,P<0.05;χ^(2)=41.13,P<0.05);10-year OSR,RSR and T50(26.54%,29.45%and 38.20 months)of patients treated with surgery were significantly higher than those of patients without surgery(7.69%,9.18%and 11.14 months);10-year OSR(35.09%)and T50(43.71 months)in the 0-49-year-old group were significantly higher than those in the 50-64-year-old group and≥65-year-old group(21.25%and 9.52%;22.59 months and 24.00 months),its RSR(35.70%)was significantly higher than that of the≥65-yearold group(14.15%);the 10-year OSR and T50 of the 50-64-year-old group were significantly higher than those of the≥65-year-old group.The results of multivariate analysis showed that the diagnosis stage,treatment mode and age had significant effects on the 10-year RSR of ovarian cancer.Conclusion The 10-year survival rate of ovarian cancer among residents of 3 cities in Liaoning Province is lower than the same per

关 键 词：卵巢癌 10年生存率 相对生存率 观察生存率 中位生存期 

分 类 号：R737.33[医药卫生—肿瘤]