FSH/LH、HOXA11、PAPP-A与CSP患者子宫动脉栓塞术后再妊娠结局关联性分析  

Association of FSH/LH,HOXA11,and PAPP-A with re-pregnancy outcome after uterine artery embolization in patients with CSP

作　　者：刘晓丽 毕颖 王绍海 陈湘玲 唐军霞 LIU Xiaoli;BI Ying;WANG Shaohai;CHEN Xiangling;TANG Junxia(Wuhan Red Cross Hospital,Wuhan,Hubei 430015,China;Union Hospital Affiliated to Huazhong Universityof Scienceand Technology,Wuhan,Hubei 430015,China)

机构地区：[1]武汉市红十字会医院,湖北武汉430015 [2]华中科技大学附属协和医院,湖北武汉430015

出　　处：《中国优生与遗传杂志》2022年第9期1597-1601,共5页Chinese Journal of Birth Health & Heredity

基　　金：湖北省科技计划项目(2017FFB6314)。

摘　　要：目的探讨卵泡刺激素(FSH)/黄体生成素(LH)、同源框基因A11(HOXA11)、妊娠相关血浆蛋白A(PAPP-A)与子宫瘢痕妊娠(CSP)患者子宫动脉栓塞术后再妊娠结局关联性。方法98例接受子宫动脉栓塞术治疗且有生育需求CSP患者,根据术后1年内是否成功再妊娠分为成功组(38例)、未成功组(60例),比较两组一般资料、术前、术后1个月、术后2个月FSH/LH、HOXA11、PAPP-A。结果成功组术后月经恢复时间早于未成功组(P<0.05);未成功组术后1个月、术后2个月FSH/LH高于成功组,HOXA11、PAPP-A低于成功组(P<0.05);术后月经恢复时间、术后1个月FSH/LH、HOXA11、PAPP-A均与再妊娠结局相关(P<0.05);FSH/LH、HOXA11、PAPP-A的AUC分别为0.754、0.801、0.767,三者联合的AUC为0.928;FSH/LH、HOXA11、PAPP-A高水平患者未成功危险度是低水平患者的2.158、0.299、0.446倍(P<0.05)。结论FSH/LH、HOXA11、PAPP-A与CSP患者子宫动脉栓塞术后再妊娠结局有关,联合检测时可为临床预测再妊娠结局提供可靠参考,从而为临床早期干预提供参考。Objective To investigate the association between follicle stimulating hormone(FSH)/luteinizing hormone(LH),homologous frame gene A11(HOXA11),pregnancy-associated plasma protein A(PAPP-A)and the outcome of recurrent pregnancy after uterine artery embolization in patients with uterine scar pregnancy(CSP).Methods Ninety-eight patients with CSP treated with uterine artery embolization and with fertility needs were divided into a successful group(38 patients)and an unsuccessful group(60 patients)according to whether they successfully re-pregnated within 1 year after surgery,and the general data,preoperative,1 month postoperative,and 2 months postoperative FSH/LH,HOXA11,and PAPP-A were compared between the two groups.Results The time to postoperative menstrual return was earlier in the successful group than in the unsuccessful group(P<0.05).FSH/LH was higher in the unsuccessful group than in the successful group at 1 month and 2months postoperatively,and HOXA11 and PAPP-A were lower than in the successful group(P<0.05).Time to postoperative menstrual return,FSH/LH at 1 month postoperatively,HOXA11,and PAPP-A were all associated with recurrent pregnancy outcome(P<0.05).The AUC of FSH/LH,HOXA11,and PAPP-A were 0.754,0.801,and 0.767,respectively,and the AUC of the three combined was 0.928,the risk of unsuccessful outcome was 2.158,0.299,and 0.446 times higher in patients with high levels of FSH/LH,HOXA11,and PAPP-A than in patients with low levels(P<0.05).Conclusion FSH/LH,HOXA11,and PAPP-A are associated with re-pregnancy outcome after uterine artery embolization in patients with CSP,and when combined,can provide a reliable reference for clinical prediction of re-pregnancy outcome,thus providing a reference for early clinical intervention.

关 键 词：FSH/LH HOXA11 PAPP-A 子宫瘢痕妊娠 子宫动脉栓塞术 

分 类 号：R713.4[医药卫生—妇产科学]