A multifunctional cholesterol-free liposomal platform based on protopanaxadiol for alopecia therapy  

作　　者：Xuefei Zhang Shuxuan Li Yating Dong Hehui Rong Junke Zhao Haiyan Hu 

机构地区：[1]School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China [2]School of Traditional Dai-Thai Medicine,West Yunnan University of Applied Sciences,Jinghong 666100,China [3]Guangdong Provincial Key Laboratory of Chiral Molecules and Drug Discovery,Sun Yat-sen University,Guangzhou 510006,China

出　　处：《Nano Research》2022年第10期9498-9510,共13页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81973264,82104080,and 81773659);Guangdong Basic and Applied Basic Research Foundation(Nos.2020A1515010593,2019A1515011954,and 2021A1515012621);Guangdong Provincial Key Laboratory of Construction Foundation(No.2019B030301005).

摘　　要：Liposome could form a long-term drug reservoir in the skin for sustained drug release,which is beneficial to improving efficacy and alleviating adverse effects.Thus,it has become a better option for anti-alopecia drugs delivery.However,cholesterol used as the fluidity buffer in conventional liposomes is a precursor for testosterone biosynthesis,which could convert to dihydrotestosterone,resulting in hair follicle damage and potentiating hair loss.To overcome the limitations,in this study we prepared a cholesterol-free liposome(PPD-Lip)using protopanaxadiol(PPD)instead of cholesterol to avoid the biosynthesis of testosterone which is adverse to alopecia therapy.PPD-Lip also worked as an active ingredient to facilitate hair growth by promoting dermal papilla cells proliferation and migration,upregulating mRNA levels of hair growth-related positive regulators,and accelerating angiogenesis in vitro.Meanwhile,it promoted hair regrowth in telogen and androgenetic alopecia mice models in vivo.In addition,our study showed that as the liposomal vehicle,PPD-Lip loaded with dutasteride exerted a stronger efficacy in the treatment of androgenetic alopecia and such a strategy could extend to other anti-alopecia agents.To the best of our knowledge,being easy for clinical transformation,the PPD-based liposomal delivery system provides a promising and multifunctional alternative platform for the delivery of alopecia treatment agents.

关 键 词：PROTOPANAXADIOL cholesterol-free liposomal platform alopecia treatment MULTIFUNCTION 

分 类 号：R98[医药卫生—药品]