PROTOPANAXADIOL

作品数：8被引量：13H指数：2
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相关领域：医药卫生更多>>
相关作者：徐晓珍宣尧仙顾利强张升辛艳飞更多>>
相关机构：浙江省医学科学院更多>>
相关期刊：《Chinese Herbal Medicines》《Medicinal Plant》《Chemical Research in Chinese Universities》《Science Bulletin》更多>>
相关基金：国家自然科学基金更多>>
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Preparation of New Doxorubicin Hydrochloride Liposomes
《Medicinal Plant》2024年第6期1-6,共6页Zhixia WANG 
[Objectives]To prepare protopanaxadiol type doxorubicin hydrochloride liposomes by replacing cholesterol with protopanaxadiol,a derivative of ginsenoside,which has a similar structure with cholesterol,to reduce the ad...
关键词：TUMOR Doxorubicin hydrochloride liposomes Targeted therapy PROTOPANAXADIOL Clinical requirement 
Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis
《Chinese Herbal Medicines》2024年第4期548-557,共10页Yue Zhou Zi Wang Shen Ren Wei Li 
supported by the grants of National Natural Science Foundation of China (No. 82104465);Changchun Science & Technology Development Plan (No. 21ZGY11);the Scientific Research Planning Project of Jilin Provincial Department of Education (No. JJKH20220371KJ)。
Hepatocellular carcinoma(HCC) is one of the most prevalent malignancies globally, posing a major challenge to global health care. Protopanaxadiol ginsenosides(PDs) have been believed to significantly improve liver dis...
关键词：anti-hepatocellular carcinoma ginsenoside Rb_(1) ginsenoside Rd ginsenoside Rg_(3) ginsenoside Rg_5 ginsenoside Rh_(2) ginsenoside Rk_(1) network pharmacology protopanaxadiol ginsenosides 
Preparation of 20 (S)-protopanaxadiol PLGA Nanoparticles
《Medicinal Plant》2024年第1期13-17,共5页Tao PAN Baifang GONG Zhixia WANG Hanyu SUN Xuanle YIN 
[Objectives]To prepare 20(S)-protopanaxadiol PLGA nanoparticles(20(S)-PPD-PLGA-NPs).[Methods]20(S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method,and the optimal formulation was screened by Box-Behn...
关键词：20(S)-protopanaxadiol PLGA nanoparticles Emulsion solvent evaporation method 
A multifunctional cholesterol-free liposomal platform based on protopanaxadiol for alopecia therapy被引量：1
《Nano Research》2022年第10期9498-9510,共13页Xuefei Zhang Shuxuan Li Yating Dong Hehui Rong Junke Zhao Haiyan Hu 
supported by the National Natural Science Foundation of China(Nos.81973264,82104080,and 81773659);Guangdong Basic and Applied Basic Research Foundation(Nos.2020A1515010593,2019A1515011954,and 2021A1515012621);Guangdong Provincial Key Laboratory of Construction Foundation(No.2019B030301005).
Liposome could form a long-term drug reservoir in the skin for sustained drug release,which is beneficial to improving efficacy and alleviating adverse effects.Thus,it has become a better option for anti-alopecia drug...
关键词：PROTOPANAXADIOL cholesterol-free liposomal platform alopecia treatment MULTIFUNCTION 
Anti-tumor Activity of Derivatives of Protopanaxadiol Prepared with Acid Anhydrides
《Medicinal Plant》2020年第1期40-43,共4页Jinna ZHOU Rongping ZHANG Cheng ZOU Weimin YANG Wenyue DUAN Chen CHEN Jianlin HU 
Supported by Science&Technology Department of Yunnan Province-Kunming Medical University Joint Fund for Applied Basic Research[2017FE468(-001)];NSFC-Yunnan Joint Fund[U1502226].
[Objectives]This paper aimed to prepare derivatives of protopanaxadiol from Panax notoginseng(Burk.)FH Chen with acid anhydrides and study their anti-tumor activity.[Methods]The 3-hydroxyl group of protopanaxadiol was...
关键词：PROTOPANAXADIOL DERIVATIVE PANAX notoginseng(Burk.)FH CHEN Structural modification 
Protopanaxadiol derivative DDPU improvesbehaviorand cognitive deficitin AD mice involving regulation of both ER stress and autophagy被引量：8
《中国药理学与毒理学杂志》2018年第4期283-283,共1页Xiao-dan Guo Jian-lu LYU Jian LU Lei FAN Xi HUANG Li-hong HU Jia-ying WANG Xu SHEN 
supported by National Natural Science Foundation of China(81220108025;81473141); NSFC-TRF collaboration projects(81561148011;DBG5980001); Drug Innovation Project of SIMM(CASIMM0120154035); Personalized Medicine-Molecular Signature-based Drug Discovery and
OBJECTIVE To explore the potential effect and mechanisms of protopanaxadiol deriva.tive 1-(3,4-dimethoxyphenethyl)-3-(3-dehydroxyl-20(s)-protopa-naxadiol-3 b-yl)-urea(DDPU) in the treatment of Alzheimer disease.METHOD...
关键词：二醇衍生物 阿尔茨海默病 临床分析 治疗方法 
Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells被引量：4
《Science Bulletin》2015年第8期773-784,M0003,共13页Sungeun Ahn Muhammad Hanif Siddiqi Hae-Yong Noh Yu-Jin Kim Yeon-Ju Kim Chi-Gyu Jin Deok-Chun Yang 
supported by a post-doctoral fellowship grant from the Kyung Hee University in 20120351
Ginsenosides, the main active constituents of Panax ginseng Meyer （P. ginseng）, have potential therapeutic effects. All tested ginsenosides except gin- senoside F1 have previously been reported in inflammation studi...
关键词：GINSENOSIDES PROTOPANAXADIOL Protopanaxatriol INFLAMMATION NF-κB/IKK RAW 264.7 
Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method for Determination of Protopanaxadiol in Rat Plasma
《Chemical Research in Chinese Universities》2009年第5期673-676,共4页WU Yi TENG Guo-sheng LIANG Yong-tao ZHONG Da-fang LIU Bing 
Supported by the National Natural Science Foundation of China(Nos.39930180 and 30070879)
A simple, rapid and sensitive method for the determination of protopanaxadiol in rat plasma with ginsenoside Rh2 as internal standard was developed and validated. The analyte and internal standard were extracted from ...
关键词：PROTOPANAXADIOL Ginsenoside Rh2 LC/MS 
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