Palladium-catalyzed cyclization of 1-alkynyl-8-iodonaphthalene and double isocyanides for the synthesis of acenaphtho[1,2-b]pyrroles  

作　　者：Shangfeng Ren Keke Huang Jin-Biao Liu Lianpeng Zhang Min Hou Guanyinsheng Qiu 

机构地区：[1]School of Metallurgical and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou 341000,China [2]College of Biological,Chemical Sciences and Engineering,Jiaxing University,Jiaxing 314001,China [3]International Joint Research Center for Biomass Materials,Southwest Forestry University,Kunming 650224,China

出　　处：《Chinese Chemical Letters》2022年第11期4870-4873,共4页中国化学快报（英文版）

基　　金：Financial supports from the Natural Science Foundation of Zhejiang Province(No.LY22B020010);the National Natural Science Foundation of China(Nos.21772067,21801096 and 22161043);The Youth Jinggang Scholars Program in Jiangxi Province。

摘　　要：A palladium-catalyzed formal[2+2+1]cyclization of 1-alkynyl-8-iodonaphthalene with double isocyanides is developed herein.The transformation worked well to produce a series of 7 H-acenaphtho[1,2-b]pyrrole with a broad reaction scope.Isocyanides play a dual role in the reaction.One is a C1 building block,and another is used as C1 N1 component.In the process,the[2+2+1]cyclization involves imidoylation,regioselective addition of imidoylpalladium species into alkyne,double imidoylation,and another addition of the resulting imidoylpalladium species into imine bonds.

关 键 词：[2+2+1]Cyclization ISOCYANIDES Palladium catalysis ALKYNE PYRROLE 

分 类 号：O626.13[理学—有机化学]