Visible-light-irradiated tandem sulfonylation/cyclization of indole tethered alkenes for the synthesis of tetrahydrocarbazoles  

作　　者：Yingjie Yu Aiyao Liu Jingrui He Chengting Wang Haibo Mei Jianlin Han 

机构地区：[1]Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,International Innovation Center for Forest Chemicals and Materials,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China

出　　处：《Chinese Chemical Letters》2022年第11期4886-4890,共5页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(No.21761132021);Qin Lan Project from Jiangsu Province for J.Han。

摘　　要：A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed,which proceeds via the sequence of reduction of sulfonyl chloride,sulfonylation,and intramolecular cyclization.This mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized tetrahydrocarbazoles in good yields.This reaction is also suitable for gram-scale synthesis,which provides an efficient and green access to multi-substituted tetrahydrocarbazoles.

关 键 词：Visible-light-irradiation SULFONYLATION Tetrahydrocarbazoles INDOLES Tandem radical reaction Sulfonyl chlorides 

分 类 号：O626[理学—有机化学]