Distinct structural characteristics define a new subfamily of Mycoplasma ferritin  

作　　者：Wenming Wang Xiaojia Liu Yajie Wang Yuan Wang Dan Fu Hongfang Xi Yi Zhao Hongfei Wang 

机构地区：[1]Institute of Molecular Science,Shanxi University,Taiyuan 030006,China [2]State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy,Nankai University,Tianjin 300350,China [3]Shanxi Key Laboratory of Pharmaceutical Biotechnology,Taiyuan 030006,China

出　　处：《Chinese Chemical Letters》2022年第11期4952-4955,共4页中国化学快报（英文版）

基　　金：supported partially by the National Natural Science Foundation of China(Nos.62075118,21601112);the Natural Science Foundation of Shanxi Province(No.20210302123433);Key R&D program of Shanxi Province(International Cooperation,No.201903D421070,2021XM21);Shanxi Key Laboratory of Pharmaceutical Biotechnology(No.KF202003);Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0020)。

摘　　要：Ferritins can generally be divided into four subfamilies based on their structural characteristics,namely,the classic ferritins(Ftns),bacterioferritins(Bfrs),DNA-binding proteins from starved cells(Dps’),and encapsulated ferritins(Enc Ftns).However,the ferritin from Mycoplasma penetrans(Mpef)possesses a particular ferroxidase center with an extreme low activity and exhibits unusual characteristics,indicating that it could be a member of a quite different subfamily of ferritins.Hereby,the crystal structure of the ferritin from Ureaplasma urealyticum(Uurf)is presented,Mpef and Uurf have very similar properties,though they display very low sequence similarity.Thus,ferritins from Mycoplasma with these unique properties do not belong to any known subfamily,but they should rather be placed in a novel ferritin subfamily,which we term Mycoplasma Ferritin(Mfr).

关 键 词：FERRITIN Ferritin subfamily UREAPLASMA MYCOPLASMA Crystal structure 

分 类 号：R341[医药卫生—基础医学]