Dihydroartemisinin-induced mitochondrial mRNA degradation and apoptosis in keloid fibroblasts  

作　　者：Qijie Li Ping Wu Yiqing Xia Dunshui Liao Yunxia Zuo Junliang Wu Qingjie Xia 

机构地区：[1]Department of Anesthesiology,Laboratory of Anesthesia and Critical Care Medicine,Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]Department of Occupational Diseases,The Second Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital,Chengdu,Sichuan 610051,China [3]Department of Biological Sciences,Xi’an Jiaotong-Liverpool University,Suzhou,Jiangsu 215123,China [4]Department of Anesthesiology,Institute of Neurological Diseases,Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [5]Department of Plastic and Burn Surgery,West China School of Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China.

出　　处：《Chinese Medical Journal》2022年第13期1613-1615,共3页中华医学杂志（英文版）

基　　金：supported by China Postdoctoral Science Foundation(No.2019M653413),Post-Doctor Research Project,West China Hospital,Sichuan University(No.2018HXBH082);the Key Project Research and Invention Program of Science and Technology Department of Sichuan Province(No.2021YFS0245)。

摘　　要：To the Editor:Keloid is a type of proliferative fibroma that may form after trauma.It is characterized by an exacerbated proliferation and inhibited apoptosis of fibroblasts coupled with an imbalance between synthesis and degradation of collagen in the extracellular matrix.[1]Although surgical resection and combined radiotherapy are effective treatment methods,keloids commonly recur after resection,resulting in decreased patient satisfaction and damage to their physical and mental health.Therefore,search for more effective treatments needs to continue.Dihydroartemisinin(DHA),a derivative of artemisinin isolated from the traditional Chinese herb by the same name,was initially employed as an effective anti-malaria agent with minimal side effects.Studies have shown that DHA prevents the progression of lung,[2]liver,[3]and kidney[4]fibrosis by inhibiting the proliferation of fibroblasts.However,DHA inhibition of keloid fibroblasts or clinical treatment of keloid has not been reported yet.This study explored the possible mechanisms involved in DHA-induced differential expression of multiple genes,mitochondrial mRNA(mt-mRNAs)degradation,cell viability inhibition,and apoptosis in keloid fibroblasts。

关 键 词：inhibited LUNG INHIBITING 

分 类 号：R622[医药卫生—整形外科]