Association between 5-HTTLPR and STin2 VNTR polymorphisms in the serotonin transporter gene and clinical response of a selective serotonin reuptake inhibitor (dapoxetine) in lifelong premature ejaculation  

作　　者：Abdullah Yang Yang Shang-Shu Ding Ping Sun Huoyong-Wei Tian Hong Junping Xing 

机构地区：[1]Department of Urology,School of Medicine,The First Affiliated Hospital,Xi’an Jiaotong University,Xi’an,Shaanxi 710061 China [2]Research Centre of Reproduction Medicine,School of Medicine,Xi’an Jiaotong University,Xi’an,Shaanxi 710061 China.

出　　处：《Chinese Medical Journal》2022年第13期1619-1621,共3页中华医学杂志（英文版）

摘　　要：To the Editor:Premature ejaculation(PE)is one of the commonplace male sexual dysfunctions affecting about 30%of men worldwide.PE can either be lifelong or acquired.Genetic polymorphisms situated on the SLC6A4 of humans encoding the 5-hydroxytryptamine transporter(serotonin transporter)(5-HTT)also called the serotonin transporter(SERT),a significant controller of serotonergic neurotransmission,were related to the pathogenesis of PE.[1,2]Polymorphisms in SLC6A4 are associated with the incidence of lifelong premature ejaculation(LPR).The effects of 5-hydroxytryptamine(serotonin)transporter gene-linked polymorphic region(5-HTTLPR)and serotonin transporter gene intron 2(STin2)polymorphism on lifelong PE(LPE)are controversial.We aimed to determine possible relationships between 5-HTTLPR and STin2 polymorphisms in the SERT gene and clinical response of a selective serotonin reuptake inhibitor(dapoxetine)in LPE.

关 键 词：SEROTONIN CLINICAL LIFE 

分 类 号：R698[医药卫生—泌尿科学]