新型冠状病毒感染动物模型应用研究进展  

Research advances in the application of animal models for SARS-CoV-2 infection

作　　者：杨波 崔倩 刘琳豆 董小艳[1] 张美云[4] 王琼[1] YANG Bo;CUI Qian;LIU Lin-dou;DONG Xiao-yan;ZHANG Mei-yun;WANG Qiong(China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;School of Public Health,Baotou Medical College,Inner Mongolia University of Science and Technology;School of Ecology and Environment,Inner Mongolia University;Department of Environmental Health,Chaoyang Center for Disease Control and Prevention)

机构地区：[1]中国疾病预防控制中心环境与人群健康重点实验室中国疾病预防控制中心环境与健康相关产品安全所,北京100021 [2]内蒙古科技大学包头医学院公共卫生学院 [3]内蒙古大学生态与环境学院 [4]北京市朝阳区疾病预防控制中心环境卫生科

出　　处：《环境卫生学杂志》2022年第10期747-756,共10页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：国家自然科学基金(42177418)。

摘　　要：新型冠状病毒肺炎(COVID-19)对人类健康以及公共安全造成了极大的影响,新冠病毒(SARS-CoV-2)的不断变异,为COVID-19预防及治疗带来新挑战。动物模型为全面认知SARS-CoV-2发病机制、疫苗开发以及治疗效果评估提供方便。不同研究中SARS-CoV-2感染动物模型的构建与使用存在一定差异,不同动物模型的应用也各具特点。本文通过查询相关文献,对SARS-CoV-2感染动物模型构建及使用现状进行综述,为COVID-19相关研究中动物模型的建立和选择提供参考。The epidemic of coronavirus disease 2019(COVID-19) has caused a great impact on human health and public safety, and the continuous variation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has brought new challenges to the research on COVID-19 prevention and treatment. Animal models provide an important research basis for comprehensive understanding the pathogenesis of SARS-CoV-2, the development of vaccines, and the evaluation of treatment outcome. There are some differences in the construction and application of various animal models for SARS-CoV-2 infection, and the application of different animal models has its own characteristics. This article reviews the current status of the construction and application of animal models for SARS-CoV-2 infection by querying relevant literature, so as to provide a reference for the establishment and selection of models in COVID-19 studies.

关 键 词：新型冠状病毒肺炎(COVID-19) 病毒感染 动物模型 模型应用 

分 类 号：R11[医药卫生—公共卫生与预防医学]