不对称催化制备手性苯并磺内酰胺的研究进展  

Research Advances on Asymmetric Catalyzed Synthesis of Chiral Benzosultams

作　　者：李延顺 曹国锐[1] 郭伟 孟春甫 滕大为[1] LI Yan-shun;CAO Guo-rui;GUO Wei;MENG Chun-fu;TENG Da-wei(College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China;Shandong DYNE Marine Biopharmaceutical Co.,Ltd.,Weihai 264300,China)

机构地区：[1]青岛科技大学化工学院,山东青岛266042 [2]山东达因海洋生物制药股份有限公司,山东威海264300

出　　处：《化学试剂》2022年第12期1712-1722,共11页Chemical Reagents

摘　　要：手性苯并磺内酰胺类化合物广泛存在于各种药物结构和天然产物中,是抗菌、抗肿瘤、抗病毒等药物的重要组成部分。有机小分子催化剂和有机金属配合物催化剂的发展,使催化不对称合成手性苯并磺内酰胺领域涌现大量研究成果。综述了手性苯并磺内酰胺的不对称催化合成方法进展,包括不对称氢化还原、有机硼试剂不对称加成、不对称傅克反应和不对称曼尼希反应等反应类型,并重点阐述了不同类型的手性催化剂或手性配体对反应产率和对映选择性的影响。Chiral benzosultams are widespread among various drug structures and natural products,and play as an important component in antibacterial drugs,antineoplastic drugs,antiviral drugs,etc.A large number of scientific research results have emerged in the field of asymmetric synthesis with the development of organocatalysts and organometallic complexes.The research advances of asymmetric catalytic synthesis reactions of chiral benzosultams,including asymmetric hydrogenation reaction was reviewed,organoboron reagent asymmetric addition reaction,asymmetric Friedel-Crafts reaction and asymmetric Mannich reaction,and the effect of chiral catalyst or chiral ligand on reaction yield and enantioselectivity was highlighted.

关 键 词：手性苯并磺内酰胺 不对称合成 手性催化剂 产率 对映选择性 

分 类 号：O625.29[理学—有机化学]