二硫代氨基甲酸盐金配合物的抗肿瘤活性研究进展  

Progress in Antitumor Activity of Dithiocarbamate Gold Complexes

作　　者：陈秋梅 陈施施 吴相华 CHEN Qiu-mei;CHEN Shi-shi;WU Xiang-hua(College of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500

出　　处：《化学试剂》2022年第12期1731-1737,共7页Chemical Reagents

基　　金：云南省科技厅科技计划项目(202001AT070068);云南师范大学大学生创新创业项目(202010681021)。

摘　　要：金属配合物作为抗癌药物的研究已受到广泛关注。金属药物的毒性、生物利用度和特异性可由金属配合物的结构和配体属性进行微调。金(Ⅰ,Ⅲ)配合物因具有优良的抗肿瘤活性被广泛研究。拥有配位功能的二硫代氨基甲酸盐具有潜在的化学保护功能,可用于治疗细菌和真菌感染,甚至癌症。稳定的二硫代氨基甲酸盐配体与金(Ⅰ,Ⅲ)的结合物因展现出优异的抗肿瘤活性而被广泛关注和研究,为癌症治疗提供了一种新的有效方法。主要综述了二硫代氨基甲酸盐金(Ⅰ)和金(Ⅲ)配合物的抗肿瘤活性研究进展,以期为相关研究和应用提供参考。The research of metal complexes as anticancer drugs has attracted extensive attention.The toxicity,bioavailability,and specificity of metallodrug candidates can be fine-tuned by the structure of metal complexes and the properties of ligand.Gold(Ⅰ,Ⅲ)complexes have been widely studied because of their excellent antitumor activity.Coordinated dithiocarbamates were reported to possess potential chemoprotective function,treatment of bacterial and fungal infections,and cancer.The combination of stable dithiocarbamate ligand and gold(Ⅰ,Ⅲ)has been widely concerned and studied because of its excellent antitumor activity,which provides a novel and effective method on cancer treatment.The research progress of antitumor activity of dithiocarbamate gold(Ⅰ)and gold(Ⅲ)complexes was reviewed,which aims to provide reference for related research and application.

关 键 词：金属药物 二硫代氨基甲酸盐 金(Ⅰ Ⅲ)配合物 抗肿瘤 作用机制 

分 类 号：R914.3[医药卫生—药物化学]