超声靶向微泡破坏实现肿瘤递药研究进展  

Progresses of ultrasound targeted microbubble destruction for antineoplastic drug delivery

作　　者：邹孝猛 毛盈譞 张羽[1] 董天秀[1] 杨秀华[1] ZOU Xiaomeng;MAO Yingxuan;ZHANG Yu;DONG Tianxiu;YANG Xiuhua(Department of Abdominal Ultrasound,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院腹部超声科,黑龙江哈尔滨150001

出　　处：《中国医学影像技术》2022年第11期1739-1742,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81871362);黑龙江省卫生计生委科研课题(2018414)。

摘　　要：超声微泡(MB)是诊断成像及药物递送的重要载体。超声靶向微泡破坏(UTMD)技术具有安全、无创、高效且可控等优点。以低强度聚焦超声(LIFU)触发UTMD可将载药MB准确送达肿瘤组织,是极具前景的靶向递药方式。本文就UTMD作用机制及其用于肿瘤递药研究进展进行综述。Ultrasound microbubble(MB) is an important carrier for diagnostic imaging and drug delivery. Ultrasound-targeted microbubble destruction(UTMD) has advantages of being safe, non-invasive, efficient and controllable. Triggered by low-intensity focused ultrasound(LIFU), drug-carrying MB can accurately delivered to tumor tissue with UTMD technology, being a promising mode of targeted drug delivery. The mechanisms of UTMD and relative research progresses in antineoplastic drug delivery were reviewed in this paper.

关 键 词：肿瘤 微泡 分子靶向治疗 超声检查 

分 类 号：R73[医药卫生—肿瘤] R445.1[医药卫生—临床医学]