The impact of social isolation on health and behavior in Drosophila melanogaster and beyond  

作　　者：Aabha Vora Andrew DNguyen Carmen Spicer Wanhe Li 

机构地区：[1]Laboratory of Genetics,The Rockefeller University,New York,New York 10065,USA [2]Department of Biology,Center for Biological Clocks Research,Texas A&M University,College Station,Texas 77843,USA

出　　处：《Brain Science Advances》2022年第3期183-196,共14页神经科学（英文）

基　　金：supported by the Cancer Prevention Institute of Texas and the Seed Grant Program for Promoting Research Collaborations from Texas A&M University。

摘　　要：Many organisms,including humans,have evolved dynamic social behaviors to promote survival.Public health studies show that isolation from social groups is a major risk factor for adverse health outcomes in humans,but these studies lack mechanistic understanding.Animal models can provide insight into the molecular and neural mechanisms underlying how social isolation impacts health through investigations using genetic,genomic,molecular,and neuroscience methods.In this review,we discuss Drosophila melanogaster as a robust genetic model for studying the effects of social isolation and for developing a mechanistic understanding of the perception of social isolation and how it impacts health.

关 键 词：social isolation DROSOPHILA MELANOGASTER GENETICS NEUROBIOLOGY BEHAVIOR LONELINESS 

分 类 号：Q42[生物学—神经生物学]