肿瘤免疫与基因治疗研究进展  

Advances in tumor immunotherapy and gene therapy

作　　者：何治尧 罗敏[1,2] 杨莉[1,2] 邓洪新 魏于全[1,2] HE ZhiYao;LUO Min;YANG Li;DENG HongXin;WEI YuQuan(Cancer Center,West China Hospital of Sichuan University,Chengdu 610041,China;State Key Laboratory of Biotherapy,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院肿瘤中心,成都610041 [2]四川大学生物治疗国家重点实验室,成都610041

出　　处：《中国科学：生命科学》2022年第11期1567-1577,共11页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:L1924039);国家自然科学基金委员会-中国科学院学部联合专项基金(批准号:XK2019SMA001)资助。

摘　　要：随着新兴免疫检查点抑制剂、溶瘤病毒和嵌合抗原受体T(chimeric antigen receptor T, CAR-T)细胞等肿瘤免疫与基因治疗制品获批临床使用,肿瘤免疫与基因治疗已经改变了实体瘤、血液肿瘤的治疗现状,在全球范围内获得权威组织、专家的广泛共识,正在成为多种肿瘤的一线治疗方案.但是,该领域目前仍然面临免疫治疗相关不良反应较多、溶瘤病毒疗效不显著的问题,而CAR-T细胞治疗有待突破实体瘤治疗的瓶颈以及下调高昂的价格等.针对这些关键科学问题,四川大学华西医院从疾病分子网络研究到创新生物技术药物研发及转化进行了一系列探索,取得了较为丰硕的成果.本文对近年来其中有关肿瘤免疫与基因治疗的研究进行综述.期待华西医院以建院130周年为契机,未来持续产出更多世界一流的成果,引领学科发展,同时造福社会.As emerging tumor immunotherapy and gene therapy products such as immune checkpoint inhibitors, oncolytic viruses and chimeric antigen receptor T(CAR-T) cells approved for clinical use, tumor immunotherapy and gene therapy have revolutionized the treatment of some solid tumors and blood tumors. On a global scale to obtain authoritative organization and leading experts of broad consensus,tumor immunotherapy and gene therapy are becoming the first-line treatment for a wide variety of tumor treatment. However, this field is still facing some questions to be solved, including the immunotherapy-related adverse reactions and the non-significant efficacy of oncolytic virus, and CAR-T cells should break through the treatment of solid tumors and reduce the expensive price.Aiming at these key scientific issues, the research teams from West China Hospital of Sichuan University have made a series of achievements from disease molecular network to drug discovery, development and translation based on innovative biotechnology.Herein, this paper briefly reviews the progress of tumor immunotherapy and gene therapy in recent years from West China Hospital of Sichuan University. We look forward to the 130th anniversary of the establishment of West China Hospital as an opportunity to continue to make more world-class achievements and benefit the society in the future.

关 键 词：免疫治疗 免疫检查点抑制剂 肿瘤疫苗 信使核糖核酸疫苗 溶瘤病毒 基因治疗 基因编辑 

分 类 号：R730.5[医药卫生—肿瘤]