From Fluorescent Probes to the Theranostics Platform  

作　　者：Peng Wei Qing Wang Tao Yi 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai,201620 China [2]Department of Chemistry,Fudan University,Shanghai,200438 China

出　　处：《Chinese Journal of Chemistry》2022年第16期1964-1974,共11页中国化学（英文版）

基　　金：the financial support from the Fundamental Research Funds for the Central Universities(2232021A-06);the National Natural Science Foundation of China(21877013,22007012,22177019);the Shanghai Sailing Program(20YF1401100).

摘　　要：Since the advent of fluorescent probes,they have been widely used in the field of life sciences.Fluorescent probes can not only light up the cells,tissues and organs,but also be used to explore the bio-distribution of specific types of disease markers.Therefore,the development of new fluorescent probes capable of recognition of bio-markers is extremely important for the diagnosis of the related diseases.Herein,we focus on our recent works experienced the evolution from the beginning of simply fluorescent probes to the construction of theranostics platform.We have developed a series of new fluorescent probes for the detecting and imaging of reactive oxygen species(ROS)and specific enzymes in vitro and in living cells.With the shift of the fluorescence signal from visible to near-infrared region,we expanded the application of the fluorescent probes from in vitro to in vivo.Very recently,we further constructed theranostics platforms to combine the diagnosis immediately with the corresponding treatment.

关 键 词：Fluorescent probes Imaging agents PRODRUGS Theranostics platform NANOPARTICLES 

分 类 号：TH77[机械工程—仪器科学与技术]