雀儿舌头化学成分的分离与鉴定  

Isolation and identification of chemical constituents from Leptopus chinensis (Bunge) Pojark.

作　　者：李平 隆李萍 陶娥 王淼 齐世洲 刘婷[2] 高慧媛[2] LI Ping;LONG Liping;TAO E;WANG Miao;QI Shizhou;LIU Ting;GAO Huiyuan(Department of Pharmaceutical Engineering,Shanxi Pharmaceutical Vocational College,Taiyuan 030031,China;School of Traditional Chinese Material Medica,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]山西药科职业学院制药工程系,山西太原030031 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2022年第10期1197-1203,共7页Journal of Shenyang Pharmaceutical University

基　　金：沈阳药科大学监管科学院项目(2021jgkx009);沈阳药科大学2019年度大学生创新创业训练计划项目(201910163134)。

摘　　要：目的 对雀儿舌头干燥药材的化学成分进行系统分离与结构鉴定,以丰富其结构多样性,为进一步开发和利用提供科学依据。方法 采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱等多种化学分离手段,对雀儿舌头体积分数75%乙醇提取物进行化学成分分离,并根据理化性质及波谱数据进行结构鉴定。结果 共分离得到12个化合物,分别为3β-O-反式咖啡酰基-11-氧代齐墩果酸-12-烯(3β-O-trans-caffeoyl-11-oxo-olean-12-en-28-oic acid,1)、脱氢山楂酸(camaldulenic acid,2)、野鸦椿酸(euscaphic acid,3)、乌苏酸(ursolic acid,4)、齐墩果酸(oleanolic acid,5)、白桦脂酸(betulinic acid,6)、木栓醇(friedelinol,7)、lyoniresinol(8)、山柰酚(kaempferol,9)、芹菜素(apigenin,10)、二氢山柰酚(dihydrokaempferol,11)、七叶亭(esculetin,12)。结论 化合物1~3、7~12为首次从雀舌木属植物中分离得到。Objective To study the chemical constituents from Leptopus chinensis,as well as to enrich the structural diversity of this plant in order to provide scientific basis for the further exploration and development.Methods By means of silica gel column chromatography, ODS column chromatography, Sephadex LH-20 column chromatography and RP-Chigh performance liquid chromatography methods, the investigation on the phytochemistry on 75% ethanol extracts of Leptopus chinensis was carried out by this work.And all compounds were identified by their physicochemical characters and spectroscopic data.Results Twelve compounds were isolated and determined as 3β-O-trans-caffeoyl-11-oxo-olean-12-en-28-oic acid(1),camaldulenic acid(2),euscaphic acid(3),ursolic acid(4),oleanolic acid(5),betulinic acid(6),friedelinol(7),lyoniresinol(8),kaempferol(9),apigenin(10),dihydrokaempferol(11) and esculetin(12).Conclusion Compounds 1-3 and 7-12 are obtained from the Leptopus genus for the first time.

关 键 词：雀儿舌头 化学成分 结构鉴定 

分 类 号：R914[医药卫生—药物化学]