中医药基于炎症信号通路调控防治2型糖尿病的研究进展  

Prevention and Treatment of Type 2 Diabetes Mellitus with Traditional Chinese Medicine Based on Inflammatory Signaling Pathways:A Review

作　　者：郭婉容 刘维 黄莉吉[2] 谢绍锋[3] GUO Wanrong;LIU Wei;HUANG Liji;XIE Shaofeng(The Third Clinical Medical College of Nanjing University of Chinese Medicine,Nanjing 210028,China;Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;Integrated Traditional Chinese and Western Medicine Hospital affiliated to Nanjing University of Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学第三临床医学院,南京210028 [2]南京中医药大学附属医院,南京210029 [3]南京中医药大学附属中西医结合医院,江苏南京210028

出　　处：《中国实验方剂学杂志》2022年第22期249-256,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省中医药局科技项目(FY201706);江苏省中医药局科技项目(YB201910)。

摘　　要：2型糖尿病(T2DM)作为一种慢性疾病,伴随着日益增加的患病率,给患者的生活质量带来了较大负担,引发了社会的广泛关注。既往研究表明炎症与T2DM的发生发展息息相关,炎症反应及其信号调控通路在T2DM发病机制中的作用已成为研究热点,通过干预炎症反应控制T2DM的进展成为治疗的新途径。随着中医药研究领域的不断深入,中医理论将炎症的生成归因于痰浊与瘀血,二者相互转化影响致使机体功能受损。而运用中药单体及中药复方基于炎症信号通路治疗糖尿病具有多靶点,多通路且不良反应少的治疗优势,能够显著缓解T2DM的症状。近年来,关于中医药干预T2DM的研究逐渐增多,该文将阐述中医对T2DM与炎症关系的认识及中医药调控T2DM炎症反应相关的7条信号通路,即核转录因子-κB(NF-κB)信号通路、丝裂原活化蛋白激酶(MAPK)依赖性信号通路、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路、蛋白激酶C(PKC)信号通路、腺苷酸活化蛋白激酶(AMPK)信号通路、Wnt信号通路、转化生长因子-β(TGF-β)信号通路。Type 2 diabetes mellitus(T2DM),as a chronic disease with an increasing prevalence,has greatly affected the quality of life of patients,and aroused widespread concern in society.Previous studies have shown that inflammation is closely related to the occurrence and development of T2DM.The role of inflammatory response and its signaling pathway in the pathogenesis of T2DM has become a research hotspot,and the intervention of inflammatory response to control the progression of T2DM has become a new approach for treatment.With the deepening in the research field of traditional Chinese medicine(TCM),the generation of inflammation is attributed to turbid phlegm and blood stasis,whose mutual transformation results in the impairment of body functions.However,the monomers and compounds of Chinese medicine in the treatment of T2DM based on inflammatory signaling pathways are advantageous in multiple targets,multiple pathways,and few side effects,which can significantly relieve the symptoms of T2DM.In recent years,there has been an increasing number of studies on TCM intervention in T2DM.The present article elaborated the understanding of the relationship between T2DM and inflammation in TCM and the seven signaling pathways related to the regulation of inflammation in T2DM by TCM,including nuclear transcription factor-κB(NF-κB)signaling pathway,mitogen-activated protein kinase(MAPK)-dependent signaling pathway,phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway,protein kinase C(PKC)signaling pathway,adenosine 5′-monophosphate(AMP)-activated kinase(AMPK)signaling pathway,Wnt signaling pathway,and transforming growth factor-β(TGF-β)signaling pathway.

关 键 词：2型糖尿病 炎症反应 信号通路 中医药 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R856.5R587.1