琥珀散治疗子宫内膜异位症研究进展  

Effect of Huposan Against Endometriosis:A Review

作　　者：张成鑫 郭滢[2] 刘芳媛 朱晓娅 韩凤娟[2] ZHANG Chengxin;GUO Ying;LIU Fangyuan;ZHU Xiaoya;HAN Fengjuan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《中国实验方剂学杂志》2022年第22期257-264,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(82074484);国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015052);黑龙江中医药大学博士创新基金项目(2019BS07)。

摘　　要：子宫内膜异位症(EMs)是常见的慢性炎症性妇科疾病,影响着全球5%~10%的育龄妇女,一直是临床医学治疗的一大挑战。琥珀散出自《普济本事方》,具有行气活血、逐瘀止痛的功效。临床中常用于治疗EMs,并取得了良好的疗效。该文通过检索中国知网(CNKI)、PubMed、万方(Wanfang Data)、维普(VIP)等数据库,对琥珀散治疗EMs的相关研究进行系统整理及归纳分析,总结琥珀散治疗EMs的作用机制及临床应用,旨在为琥珀散的基础研究及临床应用的推广提供思路及参考。在基础实验方面,琥珀散可通过减少细胞间黏附分子-1(ICAM-1)含量抗细胞黏附;降低基质金属蛋白酶(MMP)-2、MMP-9浓度抗异位内膜侵袭;抑制血管内皮生长因子(VEGF)表达抗血管生成;抑制肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-1表达,逆转辅助性T细胞(Th)1/Th2漂移调节机体免疫机制及降低血清一氧化氮(NO)、一氧化氮合酶(NOS)水平等多方面对EMs发挥治疗作用。在临床中,琥珀散具有缩小异位病灶、缓解疼痛症状、降低血清癌抗原125(CA125)含量、改善激素水平、调节内分泌和免疫因子、减少术后复发率等作用。琥珀散通过多靶点、多机制发挥对EMs的治疗作用,值得后续更深一步的挖掘探索及临床推广。Endometriosis(EMs)is a common chronic inflammatory gynecological disease,affecting about 5%-10%of women of childbearing age worldwide,and has always been a major challenge in clinical treatment.Huposan,derived from the Experiential Prescriptions for Universal Relief(《普济本事方》),has the effects of moving qi,activating blood,expelling blood stasis,and relieving pain.It is often used to treat EMs clinically and has achieved good curative effect.The relevant studies on the treatment of EMs by Huposan were retrieved from databases,such as CNKI,PubMed,Wanfang Data,and VIP for summarizing the mechanisms of action and clinical application of Huposan in the treatment of EMs,aiming to provide ideas and references for the basic research and clinical application of Huposan.As revealed by basic experiments,Huposan could exert therapeutic effects on EMs through resisting cell adhesion by reducing intercellular adhesion molecule 1(ICAM-1)content,decreasing concentrations of matrix metalloproteinase(MMP)-2 and MMP-9 against ectopic endometrial invasion,inhibiting vascular endothelial growth factor(VEGF)expression for antiangiogenesis,inhibiting the expression of tumor necrosis factor-α(TNF-α),interleukin(IL)-6,and IL-1,reversing helper T cel(l Th)1/Th2 balance shifts to regulate the body's immune mechanism,and reducing the serum levels of nitric oxide(NO)and nitric oxide synthase(NOS).In clinic practice,Huposan has the effects of reducing ectopic lesions,relieving pain symptoms,reducing serum carbohydrate antigen 125(CA125)content,improving hormone levels,regulating endocrine and immune factors,and reducing postoperative recurrence rate.Huposan plays a therapeutic role in EMs through multiple targets and mechanisms,which is worthy of further exploration and clinical promotion.

关 键 词：琥珀散 子宫内膜异位症(EMs) 作用机制 临床应用 研究进展 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R856.5R711.71R289