基于阴阳理论研究中医药干预细胞焦亡的研究进展  

TCM Intervention on Pyroptosis Based on Yin-Yang Theory:A Review

作　　者：杜沁圆 秦聪聪 张义敏[1] 孙美灵 马希骏 李成[1] 张思超[1] DU Qinyuan;QIN Congcong;ZHANG Yimin;SUN Meiling;MA Xijun;LI Cheng;ZHANG Sichao(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国实验方剂学杂志》2022年第22期276-282,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81173183);山东中医药大学科学基金项目(2018zk06);山东省高等学校青创人才引育计划-中医经典肾脏象理论及主骨生髓生物学机制研究创新项目;山东中医药大学青年科研创新团队(自然科学类)-经典名方防治骨质疏松青年科研创新团队项目。

摘　　要：细胞焦亡是一种炎症细胞程序性死亡方式,gasdermin家族(形成孔隙的效应蛋白家族)的多种成员主要通过激活胱天蛋白酶(Caspase)进行聚合和剪切,参与多种疾病的病理过程,如癌症、心肌缺血、肾损伤、骨关节炎等。细胞焦亡具有双向调节作用。诱导细胞焦亡的发生可促进病理条件下细胞的清除(如癌症、肿瘤细胞等),但长期诱导的细胞焦亡可导致体内脂质和相关维生素代谢异常。调节焦亡和细胞增殖之间的平衡是中医药治疗疾病的一个重要靶点。阴阳学说贯穿中医诊断和治疗的全过程,用来解释人体的生理和病理变化,指导理论、疾病的诊断和治疗及保健。细胞增殖与细胞焦亡之间的平衡本质上是阴阳平衡在细胞水平上的体现,阴阳自和理论对阴阳平衡加以主导。中医药对细胞焦亡的干预主要体现在促进细胞焦亡(损其有余)和抑制细胞焦亡(补其不足)上,这与调节阴阳具有相同的意义。基于这一理论,该文通过阴阳学说揭示了中医抑制和促进细胞焦亡的关系,以期为阴阳学说的现代化提供理论支持,为疾病的诊断和治疗提供新的目标。Cell pyroptosis is a programmed death of inflammatory cells.Many members of the gasdermin family(the effector protein family that forms pores)participate in the pathological process of a variety of diseases,such as cancer,myocardial ischemia,renal injury,and osteoarthritis,mainly by activating cysteine aspartate-specific protease(Caspase)for polymerization and shear.Cell pyroptosis has bidirectional regulation.Induction of pyroptosis can promote cell clearance under pathological conditions(such as cancer and tumor cells),but long-term induction of pyroptosis can lead to abnormal lipid and related vitamin metabolism in vivo.Regulating the balance between cell pyroptosis and proliferation is an important target for traditional Chinese medicine(TCM)treatment of diseases.The Yin-Yang theory runs through the whole process of TCM diagnosis and treatment,which is used to explain the physiological and pathological changes of human body and guide the theory,diagnosis and treatment of diseases and health care.The balance between cell proliferation and pyroptosis is essentially the embodiment of Yin-Yang balance at the cellular level,and the theory of Yin-Yang spontaneous harmonization dominates the balance.TCM intervention on cell pyroptosis is mainly reflected in promoting and inhibiting cell pyroptosis,which has the same significance as Yin-Yang regulation.Based on this theory,this paper revealed the relationship between TCM inhibiting and promoting cell pyroptosis through the Yin-Yang theory,to provide theoretical support for the modernization of the Yin-Yang theory and new goals for the diagnosis and treatment of diseases.

关 键 词：细胞焦亡 中医药 阴阳理论 调整阴阳 胱天蛋白酶(Caspase) gasdermin家族 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R285R96