鼻咽癌放化疗患者口腔感染因素分析  

Analysis on the causes of oral infection in the patients with nasopharyngeal carcinoma undergoing radiotherapy and chemotherapy

作　　者：丁丽莎 焦薇[2] 万蓉[3] 王素琴[4] 朱康平[1] Ding Lisha;Jiao Wei;Wan Rong;Wang Suqin;Zhu Kangping(Department of Rehabilitation Medicine and Neurology,No.904 Hospital,Joint Logistics Support Force,PLA,Wuxi 214000,China)

机构地区：[1]中国人民解放军联勤保障部队第九○四医院康复神经内科二区,江苏无锡214000 [2]中国人民解放军联勤保障部队第九○四医院机关部门,江苏无锡214000 [3]中国人民解放军联勤保障部队第九○四医院质管办,江苏无锡214000 [4]中国人民解放军联勤保障部队第九○四医院普外科,江苏无锡214000

出　　处：《海军医学杂志》2022年第10期1128-1131,1140,共5页Journal of Navy Medicine

基　　金：中国人民解放军联勤保障部队第九○四医院康复神经内科二区,江苏无锡214000。

摘　　要：目的 调查鼻咽癌放化疗患者口腔感染的相关因素和主要因素,并采取相应的预防护理对策。方法 选取2019年8月至2020年8月于中国人民解放军联勤保障部队第九○四医院行放化疗的鼻咽癌患者156例,获取患者完整临床资料,将未出现口腔感染的患者作为未感染组,出现口腔感染的患者作为感染组,并采用单因素分析法和多因素Logistic分析法分析导致鼻咽癌放化疗患者口腔感染的相关因素和独立危险因素。结果 选取的156例患者中,有19例发生口腔感染,发生率为12.18%。糖尿病、吸烟史、癌症分期、口腔病史、义齿、放化疗周期、抗生素应用、血清白蛋白水平、口腔感染等均为鼻咽癌放化疗患者口腔感染发生的相关因素(P<0.05);以单因素分析具有统计学意义的指标作为自变量予以赋值再进行多因素分析,结果显示多次放化疗周期、口腔pH值>6.5、血清白蛋白水平<40 g/L、住院前口腔感染等均为鼻咽癌放化疗患者口腔感染发生的独立危险因素(P<0.05)。结论 多因素Logistic分析表明放化疗周期(多次)、口腔pH值(>6.5)、血清白蛋白水平(<40 g/L)及住院前口腔感染等均是鼻咽癌放化疗患者口腔感染发生的重要因素,临床护理应强化对上述因素的重视,采取相应的预防措施的同时,减少口腔感染的发生,提高患者生活质量。Objective To investigate the related factors and main factors inducing oral infection in the patients with nasopharyngeal carcinoma undergoing radiotherapy and chemotherapy,so as to take corresponding preventive nursing measures.Methods 156 patients with nasopharyngeal carcinoma undergoing radiotherapy and chemotherapy in the hospital from August 2019 to August 2020 were selected as research subjects and complete data of the patients were collected for analysis.The patients with or without infection were divided into the study group and the control group.The related factors and independent risk factors inducing oral infection in the patients with nasopharyngeal carcinoma undergoing radiotherapy and chemotherapy were analyzed by univariate analysis and multivariate Logistic analysis.Results Of the 156 patients selected,19 developed oral infection with an incidence of 12.18%.Diabetes,smoking history,cancer stage,oral illness history,denture,chemoradiotherapy cycle,antibiotic application,serum albumin level(g/L),oral infection were all related factors inducing oral infection(P<0.05).Given as independent variables by univariate analysis,the end results showed that multiple chemoradiotherapy cycle,oral PH value>6.5,serum albumin level<40 g/L,and oral infection were all independent risk factors in NPC patients(P≤0.05).Conclusion Multivariate Logistic analysis indicated that(multiple) radiotherapy and chemotherapy cycles,oral PH(>6.5),serum albumin level(<40 g/L) and oral infection before hospitalization are all important factors of oral infection in nasopharyngeal cancer and chemotherapy patients.Attention should be paid to the above factors in clinical care and related preventive measures be taken at the same time,so as to reduce the incidence of oral infection of the patients and improve their life quality.

关 键 词：鼻咽癌 放化疗 口腔感染 原因 预防护理 

分 类 号：R739.63[医药卫生—肿瘤]