Kalihioxepanes A-G:Seven Kalihinene Diterpenoids from Marine Sponge Acanthella cavernosa Collected off the South China Sea  

作　　者：Zhe Wang Xiao Han Guoping Liu Di Zhang Huiyue Hou Li Xiao Nicole J.de Voogd Xuli Tang Pinglin Li 

机构地区：[1]Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003,China [2]Laboratory of Marine Drugs and Biological Products,National Laboratory for Marine Science and Technology,Qingdao,Shandong 266235,China [3]National Museum of Natural History,2300 RA Leiden,The Netherlands [4]College of Chemistry and Chemical Engineering,Ocean Universityof China,Qingdao,Shandong 266100,China

出　　处：《Chinese Journal of Chemistry》2022年第15期1785-1792,共8页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.U2006204,41776136,2181101213,81991522,and 41876161)。

摘　　要：Comprehensive Summary Seven new kalihinene diterpenoids,kalihioxepanes A-G(1-7)bearing a rare oxepane ring,were isolated from sponge Acanthella cavernosa collected from the South China Sea.The structures and absolute configurations were elucidated by comprehensive spectroscopic analysis,single crystal X-ray diffraction,and quantum chemical calculation methods.Kalihioxepane A(1)displayed strong cytotoxicity against H69 and K562 tumor cells,while kalihioxepane B(2)showed moderate cytotoxicity against K562 cells.

关 键 词：Acanthella cavernosa Kalihinenes Configuration determination CYTOTOXICITY Natural products 

分 类 号：O62[理学—有机化学]