重视眼表微生物组在眼部感染性炎症诊断与治疗中的价值  

Pay attention to the value of ocular surface microbiome in the diagnosis and treatment of ocular infection and inflammation

作　　者：郑美琴[1] 康雨童 楼永良[3] Zheng Meiqin;Kang Yutong;Lou Yongliang(School of Ophthalmology,Wenzhou Medical University,Affiliated Ophthalmology Hospital,National Ophthalmology Clinical Research Center and Laboratory Pathology Center,Wenzhou 325027,China;Institute of Infectious Diseases Prevention and Control,China Center for Disease Control and Prevention,State Key Laboratory of Infectious Diseases Prevention and Control,Beijing 102206,China;School of Laboratory Medicine,Wenzhou Medical University,Key Laboratory of Laboratory Medicine,Ministry of Education,Wenzhou Key Laboratory of Environmental Hygiene Microbiology,Wenzhou 325000,China)

机构地区：[1]温州医科大学眼视光学院附属眼视光医院检验病理中心,国家眼科临床研究中心,325027 [2]中国疾病预防控制中心传染病预防控制所,传染病预防控制国家重点实验室,生物安全实验室,北京102206 [3]温州医科大学检验医学院检验医学教育部重点实验室,温州市环境卫生微生物检验重点实验室,325000

出　　处：《中华眼科医学杂志（电子版）》2022年第1期1-5,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：国家科技重大课题专项子课题(2018zx10201001)。

摘　　要：16S核糖体核糖核酸(16S rRNA)基因测序和二代测序(NGS)技术的应用促进了人类微生物组的研究,改变了业界对人类健康与微生物关系的认知。近年来,对微生物组与眼健康的关系研究已经成为一个新兴的研究领域。已有证据表明,眼部疾病不仅与眼表微生物组的改变有关,还与肠道及口腔微生态失调相关;了解微生物群在眼部疾病特别是与感染性炎症相关疾病中的作用机制,已成为精准诊断与治疗此类疾病的关键。然而,微生物群具有多样而复杂的特性,加之眼部组织结构的特殊,使之注定成为一项具有巨大挑战的使命。迄今为止,虽然业内对其关联机制的认知尚处于起步阶段,但笔者相信这一领域的持续进展必将为众多眼科疾病的诊断与治疗打开一个新的局面。16S ribosomal ribonucleic acid(16S rRNA)genome sequencing and second-generation sequencing(NGS)technology have promoted the research in the field of human microbiome,which have changed the understanding of the relationship between human health and microorganisms for researchers.Recently,the research on the relationship between eye microbiome and eye health,as a branch,has also become a new research field.It has demonstrated that eye diseases were not only related to the changes of eye surface microbiome,but also the imbalance of intestinal and oral microecology.Understanding the role of microbiota in eye diseases,especially for related infectious inflammation,has become the key to accurate diagnosis and treatment of such diseases.However,it was destined to become a challenging mission because of the diverse and complex characteristics of microbiota,coupled with the special structure of ocular tissue.So far,although the industry′s understanding of its association mechanism remains to develope,authors believe that the continuous progress in this field will be helpful to reshape the industry of the diagnosis and treatment for many ophthalmic diseases.

关 键 词：眼感染 炎症 微生物组 基因组测序 

分 类 号：R739.7[医药卫生—肿瘤]