利奈唑胺骨水泥在关节置换感染中的应用进展  

Application of linezolid bone cement in periprosthetic joint infection

作　　者：孙长鲛[1] 马琦 房立业 许平平 李慧敏[1] 蔡谞 Sun Changjiao;Ma Qi;Fang Liye;Xu Pingping;Li Huimin;Cai Xu(Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China)

机构地区：[1]清华大学附属北京清华长庚医院,清华大学临床医学院,102218

出　　处：《中华关节外科杂志（电子版）》2022年第2期190-195,共6页Chinese Journal of Joint Surgery(Electronic Edition)

基　　金：福建省卫生教育联合攻关项目(2019-WJ-01)。

摘　　要：使用抗生素骨水泥占位器的二期翻修一直是治疗假体周围感染的金标准。目前常用的添加到骨水泥中的抗生素包括庆大霉素,妥布霉素和万古霉素。但是目前对这几种抗生素耐药的细菌越来越多,因此需要除了氨基糖苷类和糖肽类以外的药物来治疗和预防假体周围感染,利奈唑胺是一个理想药物,它对革兰氏阳性病原体有高度抗菌活性,对骨骼的渗透性能好,并对生物膜中的活跃生长和静止期病原体均有抗菌活性,利奈唑胺对产生生物膜的葡萄球菌显示出与万古霉素相似或更高的疗效。这些特点对于假体周围感染的治疗至关重要。本文对利奈唑胺骨水泥在关节置换术感染中的应用进展进行综述。Two-stage revision with antibiotic bone cement spacer has been the gold standard for the treatment of periprosthetic joint infections.Now,the most commonly used antibiotics added to bone cement include gentamicin,tobramycin and vancomycin.However,there are more and more bacteria resistant to these antibiotics.Therefore,drugs other than aminoglycosides and glycopeptides are needed to treat and prevent periprosthetic joint infections.Linezolid is an ideal drug.It has high antibacterial activity to Gram-positive pathogens,which also have good permeability to joint and bones.Linezolid has antibacterial activity against active growth and resting pathogens in biofilms which is very important for treatment of periprosthetic joint infections.Linezolid shows similar or higher efficacy to vancomycin,against staphylococcus producing biofilms.This article reviewed the progress of linezolid bone cement in periprosthetic joint infections.

关 键 词：利奈唑酮 抗菌药 骨黏合剂 关节成形术 置换 感染 

分 类 号：R687.4[医药卫生—骨科学]