PAK5和E-cadherin在肺腺癌组织中的表达及其临床意义  

EXPRESSION OF PAK5 AND E-CADHERIN IN LUNG ADENOCARCINOMA TISSUE AND ITS CLINICAL SIGNIFICANCE

作　　者：王雅玲 徐静[2] 赵鹏[3] 孙伟红 彭达 马学真[1] WANG Yaling;XU Jing;ZHAO Peng;SUN Weihong;PENG Da;MA Xuezhen(Department of Oncology Center,The Second Clinical Medical College of Qingdao University,Qingdao 266042,China)

机构地区：[1]青岛大学第二临床医学院肿瘤中心,山东青岛266042 [2]青岛大学第二临床医学院病理科,山东青岛266042 [3]青岛大学第二临床医学院生物治疗中心,山东青岛266042

出　　处：《精准医学杂志》2022年第6期502-506,共5页Journal of Precision Medicine

基　　金：青岛市应用基础研究计划项目(18-2-2-78-JCH)。

摘　　要：目的探究P21活化激酶5(PAK5)和E-钙黏蛋白(E-cadherin)在肺腺癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测61例肺腺癌组织标本中PAK5以及E-cadherin的表达,并分析PAK5与E-cadherin表达的相关性及与患者临床病理特征和预后的关系。结果61例肺腺癌组织标本中PAK5高表达38例(62.3%),E-cadherin高表达43例(70.5%)。PAK5和E-cadherin的表达水平均与肿瘤T分期、有无淋巴结转移和TNM分期有关(χ^(2)=4.037~16.108,P<0.05),而均与患者的年龄、性别及是否吸烟无关(P>0.05)。PAK5与E-cadherin的表达水平呈负相关(r=-0.355,P<0.05)。PAK5低表达患者3年总生存率和3年无进展生存率均高于高表达患者(χ^(2)=5.893、3.920,P<0.05);E-cadherin高表达患者3年总生存率和3年无进展生存率均高于低表达患者(χ^(2)=5.849、7.363,P<0.05)。结论PAK5高表达和E-cadherin低表达与肺腺癌的浸润、转移及不良预后有关,且PAK5可能通过调控上皮-间质转化促进肺腺癌的进展。Objective To investigate the expression of P21-activated kinase 5(PAK5)and epithelial cadherin(E-cadhe-rin)in the lung adenocarcinoma(LAC)tissue and its clinical significance.Methods Immunohistochemistry was used to determine the expression of PAK5 and E-cadherin in 61 LAC tissue samples.The correlation between the expression of PAK5 and E-cadherin,as well as their relationship with the clinicopathological characteristics and prognosis of patients with LAC,was analyzed.Results Among the 61 LAC tissue samples,38(62.3%)showed high PAK5 expression and 43(70.5%)showed high E-cadherin expression.The expression levels of PAK5 and E-cadherin were both correlated with T stage,the presence or absence of lymph node metastasis,and TNM stage(χ^(2)=4.037-16.108,P<0.05),and were not correlated with age,sex,and smoking status(P>0.05).PAK5 expression was negatively correlated with E-cadherin expression(r=-0.355,P<0.05).The 3 year overall survival rate and 3 year progression-free survival rate in the low PAK5 expression patients were significantly higher than those in the high PAK5 expression patients(χ^(2)=5.893,3.920,P<0.05);the 3 year overall survival rate and 3 year progression-free survival rate in the high E-cadherin expression patients were significantly higher than those in the low E-cadherin expression patients(χ^(2)=5.849,7.363,P<0.05).Conclusion High PAK5 expression and low E-cadherin expression are associated with invasion,metastasis,and poor prognosis of LAC,and PAK5 may promote the progression of LAC by regulating epithelial-mesenchymal transition.

关 键 词：p21活化激酶类 钙黏着糖蛋白类 上皮-间质转化 肺腺癌 预后 病理状态 体征和症状 

分 类 号：R730.261.1[医药卫生—肿瘤]