贲门癌淋巴结转移规律及其影响因素  

LYMPH NODE METASTASIS PATTERN OF CARDIA CANCER AND ITS INFLUENCING FACTORS

作　　者：李川[1] 李春峰 李彩莲 杨荣华[1] 王茂龙[1] LI Chuan;LI Chunfeng;LI Cailian;YANG Ronghua;WANG Maolong(Department of Thoracic Surgery,The Affiliated Hospital of Qingdao Univer-sity,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院胸外科,山东青岛266003 [2]中国人民解放军海军第971医院信息科

出　　处：《精准医学杂志》2022年第6期536-538,544,共4页Journal of Precision Medicine

摘　　要：目的探讨贲门癌淋巴结转移的规律及其影响因素。方法回顾性分析2017年1月-2019年12月于我院胸外科行手术治疗的61例贲门癌患者的临床资料,统计胸腔、腹腔淋巴结转移数及转移比例,分析其病理学特点与淋巴结转移的相关性。结果61例患者共清扫淋巴结828枚,病理学检查证实癌转移的阳性淋巴结165枚(19.9%);其中清扫胸腔淋巴结243枚,胸腔癌转移阳性淋巴结27枚(11.1%),清扫腹腔淋巴结585枚,腹腔癌转移阳性淋巴结138枚(23.6%)。肿瘤浸润深度和肿瘤细胞分化程度对贲门癌淋巴结转移有显著影响(χ^(2)=16.796、8.765,P<0.05),肿瘤浸润深度越浅,淋巴结转移危险性越小(OR=0.306,95%CI=0.102~0.915,P<0.05),而肿瘤细胞分化程度越低,淋巴结转移的危险性越大(OR=3.032,95%CI=1.200~7.657,P<0.05)。结论贲门癌淋巴结转移率较高,以腹腔淋巴结转移为主。贲门癌肿瘤浸润深度和肿瘤细胞分化程度是贲门癌淋巴结转移的独立危险因素。Objective To investigate the lymph node metastasis pattern of cardia cancer and its influencing factors.Methods A retrospective analysis was performed for the clinical data of 61 patients with cardiac cancer who underwent surgical treatment in Department of Thoracic Surgery in our hospital from January 2017 to December 2019.A statistical analysis was performed for the number and proportion of lymph node metastases in the thoracic cavity and the abdominal cavity,and the association between pathological features and lymph node metastases was analyzed.Results A total of 828 lymph nodes were dissected for all 61 patients,among which 165(19.9%)were positive lymph nodes with pathologically confirmed tumor metastasis;among the 243 thoracic lymph nodes dissected,27(11.1%)were positive lymph nodes with thoracic tumor metastasis,and among the 585 abdominal lymph nodes dissected,138(23.6%)were positive lymph nodes with abdominal tumor metastasis.The depth of tumor invasion and the degree of tumor cell differentiation had a significant impact on the lymph node metastasis of cardia cancer(χ^(2)=16.796,8.765,P<0.05).The risk of lymph node metastasis decreased with the reduction in the depth of tumor invasion(OR=0.306,95%CI=0.102-0.915,P<0.05),while it increased with the reduction in the degree of tumor cell differentiation(OR=3.032,95%CI=1.200-7.657,P<0.05).Conclusion Cardia cancer has a high rate of lymph node metastasis,occurring mainly in the abdominal cavity.The depth of tumor invasion and the degree of tumor cell differentiation are independent risk factors for the lymph node metastasis of cardia cancer.

关 键 词：贲门 胃肿瘤 淋巴转移 肿瘤浸润 细胞分化 影响因素分析 

分 类 号：R735.2[医药卫生—肿瘤]